In the early 1990s, Microcebus murinus, a small primate endemic to Madagascar, emerged as a potential animal model for the study of aging and Alzheimer’s disease. This paper traces the use of the lesser mouse lemur in research on aging and associated neurodegenerative diseases, focusing on a basic material precondition that made this possible, namely, the conversion of a wild animal into an experimental organism that lives, breeds, and survives in the laboratory. It argues that the “old” mouse lemur model can be considered as an eco-zootechnical acquisition. This is shown by examining how, since the early 1970s, French mouse lemur researchers have articulated colony productivity and viability with the influence of environmental factors on the demographics and physiology of the species. The appearance and maintenance of a growing number of old mouse lemurs in French research facilities are related to three developments: the application of the ecological notion of “social stress” to the understanding and management of the behavior of the captive population; the experimental demonstration that a variety of seasonal physiological changes in the species were influenced by the photoperiod; and the related attempt to accelerate aging in mouse lemurs through the manipulation of annual light conditions.

中文翻译：

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变老的艺术：环境操纵，生理节律以及作为衰老的灵长类动物模型的鼠尾草的出现。

在1990年代初，Microcebus murinus是马达加斯加特有的小型灵长类动物，已成为研究衰老和阿尔茨海默氏病的潜在动物模型。本文追踪了小狐猴在衰老和相关神经退行性疾病研究中的用途，着眼于使之成为可能的基本物质前提，即将野生动物转化为能够在其中生存，繁殖和存活的实验生物。实验室。它认为“老”小鼠狐猴模型可以被认为是一种生态动物技术的获取。自1970年代初以来，法国老鼠狐猴研究人员如何通过环境因素对物种的人口统计学和生理学的影响，阐明其殖民地生产力和生存能力，就可以证明这一点。在法国的研究机构中，越来越多的老狐猴的出现和维持与三项发展有关：“社会压力”的生态概念在对圈养人群行为的理解和管理中的应用；实验表明，光周期影响了物种的各种季节性生理变化；以及通过操纵年度光照条件来加速小鼠狐猴衰老的相关尝试。