A novel library of chalcone linked thiazole-imidazopyridine (12a–j) derivatives were designed, synthesized, and their structures were characterized by ¹H NMR, ¹³C NMR and mass spectral studies. Further, all compounds were tested for their anticancer effects on four human cancer cell lines including MCF-7 (breast carcinoma), A549 (lung carcinoma), DU-145 (prostate carcinoma) and MDA MB-231 (breast carcinoma) by employing MTT method, using etoposide as the positive control. Among them, compound 12b displayed more potent anticancer activity against four cancer cell lines when compared to the positive control.

中文翻译：

---

查尔酮连接的噻唑-咪唑并吡啶衍生物作为抗癌剂的设计，合成及生物学评价

设计，合成了查尔酮连接的噻唑-咪唑并吡啶（12a–j）衍生物的新文库，并通过¹ H NMR，¹³ C NMR和质谱研究对它们的结构进行了表征。此外，通过使用MTT测试了所有化合物对四种人类癌细胞系的抗癌作用，包括MCF-7（乳腺癌），A549（肺癌），DU-145（前列腺癌）和MDA MB-231（乳腺癌）方法，使用依托泊苷作为阳性对照。其中，与阳性对照相比，化合物12b对四种癌细胞系表现出更强的抗癌活性。