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Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents

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Abstract

A novel library of chalcone linked thiazole-imidazopyridine (12a–j) derivatives were designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and mass spectral studies. Further, all compounds were tested for their anticancer effects on four human cancer cell lines including MCF-7 (breast carcinoma), A549 (lung carcinoma), DU-145 (prostate carcinoma) and MDA MB-231 (breast carcinoma) by employing MTT method, using etoposide as the positive control. Among them, compound 12b displayed more potent anticancer activity against four cancer cell lines when compared to the positive control.

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Authors and Affiliations

  1. Department of Chemistry, , GITAM Institute of Science Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, Andhra Pradesh, 530045, India

    Vellanki Ragha Suma & Kuppili Ram Mohan Rao

  2. Department of Chemistry, Government Degree and PG College, Bhadrachalam, Telangana, 507111, India

    Vellanki Ragha Suma

  3. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India

    Reddymasu Sreenivasulu

  4. Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001, India

    Mandava Venkata Basaveswara Rao

  5. Department of Chemistry, SR and BGNR Govt. Arts and Science College (Autonomous), Khammam, Telangana, 507002, India

    Madala Subramanyam

  6. Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Ambabari Circle, Jaipur, Rajasthan, India

    Mohamed Jawed Ahsan

  7. Vishnu Institute of Pharmaceutical Education & Research (VIPER), Narsapur, Medak, Telangana, 502313, India

    Ramesh Alluri

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  1. Vellanki Ragha Suma
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  2. Reddymasu Sreenivasulu
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Suma, V.R., Sreenivasulu, R., Rao, M.V.B. et al. Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents. Med Chem Res 29, 1643–1654 (2020). https://doi.org/10.1007/s00044-020-02590-9

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