Abstract Bioactivity-guided phytochemical investigation of Cucumis bisexualis has led to the isolation of three new coumarin-aurone heterodimers (1-3), along with six aurone derivatives (4-9) were isolated from C. bisexualis for the first time. Their structures were determined by their extensive spectroscopic data and comparison with the values reported in the references. All isolated compounds (1-9) were evaluated for their hepatoprotective activities on human L-O2 cells, which compared with positive control of Bifendatatum. Among them, compounds 1, 2, and 7 exhibited moderate hepatoprotective activities to promote effects on the proliferation of L-O2 cells.

中文翻译：

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生物活性引导下从双性黄瓜果实中分离具有保肝活性的金酮衍生物

摘要 以生物活性为导向的双性黄瓜植物化学研究已分离出三种新的香豆素-金酮异二聚体 (1-3)，并首次从双性恋黄瓜中分离出 6 种金酮衍生物 (4-9)。它们的结构是通过广泛的光谱数据和与参考文献中报道的值进行比较来确定的。评估所有分离的化合物 (1-9) 对人 L-O2 细胞的保肝活性，与双芬数据的阳性对照相比。其中，化合物1、2和7表现出中等的保肝活性，促进L-O2细胞增殖。