Abstract
Bioactivity-guided phytochemical investigation of Cucumis bisexualis has led to the isolation of three new coumarin-aurone heterodimers (1-3), along with six aurone derivatives (4-9) were isolated from C. bisexualis for the first time. Their structures were determined by their extensive spectroscopic data and comparison with the values reported in the references. All isolated compounds (1-9) were evaluated for their hepatoprotective activities on human L-O2 cells, which compared with positive control of Bifendatatum. Among them, compounds 1, 2, and 7 exhibited moderate hepatoprotective activities to promote effects on the proliferation of L-O2 cells.
Funding source: The National Natural Science Foundation of China
Award Identifier / Grant number: 81803843
Award Identifier / Grant number: 19A350006
Funding source: Scientific Research Project of Jiangxi Administration of Traditional Chinese Medicine
Award Identifier / Grant number: 2019A002
Award Identifier / Grant number: 2019A018
Funding source: Standard Revision Research Project of National Pharmacopoeia Committee
Award Identifier / Grant number: 2018Z090
Funding source: Science and Technology Project of Jiangxi Health Commission
Award Identifier / Grant number: 20195648
Award Identifier / Grant number: 20195650
Funding source: Science and Technology Project of Jiangxi Provincial Department of Education
Award Identifier / Grant number: GJJ180662
Award Identifier / Grant number: GJJ180688
Funding source: Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM
Award Identifier / Grant number: JXSYLXK-ZHYAO027
Award Identifier / Grant number: JXSYLXK-ZHYAO032
Funding source: Doctoral Research Initiation Fund Project of Jiangxi University of TCM
Award Identifier / Grant number: 2018BSZR007
Award Identifier / Grant number: 2018BSZR010
Acknowledgments
This study was supported by the National Natural Science Foundationof China (81803843), the Key Scientific Research Project of Colleges and Universities in Henan Province (19A350006), the Scientific Research Project of Jiangxi Administration of Traditional Chinese Medicine (2019A002,2019A018), the Standard Revision Research Project of National Pharmacopoeia Committee (2018Z090), the Science and Technology Project of Jiangxi Health Commission (20195648,20195650), the Science and Technology Project of Jiangxi Provincial Department of Education (GJJ180662,GJJ180688), the Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM (JXSYLXK-ZHYAO027, JXSYLXK-ZHYAO032), and the Doctoral Research Initiation Fund Project of Jiangxi University of TCM (2018BSZR007,2018BSZR010).
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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