Abstract Polymer composites offer a great advantage in biomedical field over the traditional materials used like, metal, ceramics, or polymer alone. Polymer composites provide tailor-made facilities to design required physiological and mechanical properties in biomedical products. Poly(lactic acid) (PLA) is a popular aliphatic polyester used in various biomedical products because they have a renewable source and after resorption they enter well into the Krebs cycle of the human body. However, PLA suffers from hydrolysis and subsequent weight loss in aqueous environment. To improve the hydrolytic properties of hydrophobic PLA and to incorporate the biocompatibility from chitosan (CS) into it, in this study CS has been grafted onto PLA film. CS with 78% of degree of deacetylation and viscosity average molecular weight of about 8,31,760 Da was grafted onto hydrolyzed PLA film surface. Kjeldahl analysis confirmed the attachment of CS onto the PLA films. From thermal stability analysis, it was observed that percentage of weight retention at 600°C of the CS-g-PLA was around 15% higher than that of pure PLA. The mechanical properties of final CS-grafted-PLA composites showed more resistance to hydrolytic degradation than that of pure PLA film.

中文翻译：

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用于生物医学复合材料的壳聚糖接枝聚乳酸薄膜的制备与表征

摘要 聚合物复合材料在生物医学领域比单独使用的金属、陶瓷或聚合物等传统材料具有很大的优势。聚合物复合材料为设计生物医学产品所需的生理和机械性能提供了量身定制的设施。聚乳酸 (PLA) 是一种流行的脂肪族聚酯，用于各种生物医学产品，因为它们具有可再生来源，并且在吸收后可以很好地进入人体的克雷布斯循环。然而，PLA 在水性环境中会发生水解和随后的重量损失。为了提高疏水性 PLA 的水解性能并将壳聚糖 (CS) 的生物相容性纳入其中，在本研究中，CS 已接枝到 PLA 薄膜上。CS具有78%的脱乙酰度和约8，31的粘均分子量，760 Da接枝到水解的PLA薄膜表面。凯氏定氮分析证实了 CS 附着在 PLA 薄膜上。从热稳定性分析中可以看出，CS-g-PLA 在 600°C 下的重量保留百分比比纯 PLA 高约 15%。最终的 CS 接枝 PLA 复合材料的机械性能显示出比纯 PLA 薄膜更好的抗水解降解能力。