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First molecular characterization of avian paramyxovirus-1 (Newcastle disease virus) in Botswana.
Virus Genes ( IF 1.9 ) Pub Date : 2020-06-20 , DOI: 10.1007/s11262-020-01770-4
Tebogo Kgotlele 1 , Boitumelo Modise 1 , John Fredrick Nyange 1 , Carter Thanda 1 , Giovanni Cattoli 2 , William G Dundon 2, 3
Affiliation  

Avian paramyxovirus-1 (APMV-1), the causative agent of Newcastle disease (ND) in domestic and wild avian species, has recently been reported and characterized in five southern African countries (i.e. Mozambique, Namibia, South Africa, Zambia and Zimbabwe). Since APMV-1s have never been characterized in Botswana, this study was undertaken to determine the genotype circulating in the country. Fourteen samples were collected from ND outbreaks in poultry in 2014, 2018 and 2019 and the complete fusion protein gene was sequenced. Phylogenetic analysis revealed that all of the viruses from Botswana clustered in genotype VII.2 (previously subgenotype VIIh) and that they were more related to viruses from South Africa and Mozambique than the other southern African countries (i.e. Namibia, Zambia and Zimbabwe).



中文翻译:

博茨瓦纳禽副粘病毒-1(新城疫病毒)的第一个分子特征。

禽副粘病毒-1(APMV-1)是新城疫(ND)在家庭和野生禽类中的致病因子,最近在南部非洲的五个国家(即莫桑比克,纳米比亚,南非,赞比亚和津巴布韦)得到了报道并进行了特征鉴定。 。由于在博茨瓦纳从未对APMV-1s进行过鉴定,因此进行了这项研究以确定该国流行的基因型。从2014年,2018年和2019年的ND禽流感暴发中采集了14个样本,并对完整的融合蛋白基因进行了测序。系统发育分析表明,来自博茨瓦纳的所有病毒都聚集在基因型VII.2(以前是亚基因型VIIh)中,与南非和莫桑比克的病毒相比,与其他南部非洲国家(即纳米比亚,赞比亚和津巴布韦)的关系更密切。

更新日期:2020-06-23
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