The purpose of our study was to evaluate the antioxidant potential of Allium sativum essential oil (ASEO) and the protective effects against deltamethrin (D) induced hepatic toxic effects in Wistar rats. Twenty-four male rats were divided into four groups as follows: control, ASEO, D and ASEO + D. Rats were orally gavaged with ASEO (200 mg/kg body weight) and D (7.2 mg/kg body weight) for 4 weeks. The ASEO revealed radical scavenging activity (DPPH) with IC₅₀ = 47.66 ± 2.51 µg/mL, and the lipid peroxidation activity (the β-carotene bleaching method) with IC₅₀ = 0.034 ± 0.007 µg/mL. Analyzed by GC–MS, ASEO confirm that disulfides (38%) and eugenol (15%) were the main components of garlic oil. In terms of in vivo study, deltamethrin exposure induced a significant increase in the biochemical serum parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO) level, advanced oxidized protein products (AOPP), and carbonyl protein accompanied by decrease in the activities of SOD, CAT, GPX and the levels of GSH (p < 0.01). This toxic effect was confirmed by histological study. The pretreatment with ASEO significantly mended the hepatic toxicity produced by deltamethrin. This finding revealed that ASEO are capable of ameliorating the hepatic oxidative damage induced by deltamethrin.

中文翻译：

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富含二硫键的大蒜提取物对溴氰菊酯致大鼠氧化应激和肝毒性的保护作用

我们的研究目的是评估Wistar大鼠的大蒜精油（ASEO）的抗氧化能力和对溴氰菊酯（D）诱导的肝毒性的保护作用。将24只雄性大鼠分为以下四组：对照组，ASEO，D和ASEO +D。大鼠分别经口灌胃ASEO（200 mg / kg体重）和D（7.2 mg / kg体重），持续4周。所述ASEO揭示自由基清除活性（DPPH）与IC ₅₀  = 47.66±2.51微克/毫升，和脂质过氧化的活性（β型胡萝卜素漂白法）用IC ₅₀ = 0.034±0.007 µg / mL。通过GC-MS分析，ASEO确认二硫化物（38％）和丁子香酚（15％）是大蒜油的主要成分。在体内研究方面，溴氰菊酯的暴露引起生化血清参数的显着增加，例如天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），碱性磷酸酶（ALP），肝脂质过氧化（LPO）水平，高级氧化蛋白产物（AOPP）和羰基蛋白伴随着SOD，CAT，GPX活性和GSH水平的降低（p <0.01）。组织学研究证实了这种毒性作用。用ASEO预处理可显着改善溴氰菊酯产生的肝毒性。该发现表明ASEO能够改善溴氰菊酯引起的肝氧化损伤。