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Protective effects of Allium sativum essential oil rich in disulfides against deltamethrin induced oxidative stress and hepatotoxicity in rats

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Abstract

The purpose of our study was to evaluate the antioxidant potential of Allium sativum essential oil (ASEO) and the protective effects against deltamethrin (D) induced hepatic toxic effects in Wistar rats. Twenty-four male rats were divided into four groups as follows: control, ASEO, D and ASEO + D. Rats were orally gavaged with ASEO (200 mg/kg body weight) and D (7.2 mg/kg body weight) for 4 weeks. The ASEO revealed radical scavenging activity (DPPH) with IC50 = 47.66 ± 2.51 µg/mL, and the lipid peroxidation activity (the β-carotene bleaching method) with IC50 = 0.034 ± 0.007 µg/mL. Analyzed by GC–MS, ASEO confirm that disulfides (38%) and eugenol (15%) were the main components of garlic oil. In terms of in vivo study, deltamethrin exposure induced a significant increase in the biochemical serum parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO) level, advanced oxidized protein products (AOPP), and carbonyl protein accompanied by decrease in the activities of SOD, CAT, GPX and the levels of GSH (p < 0.01). This toxic effect was confirmed by histological study. The pretreatment with ASEO significantly mended the hepatic toxicity produced by deltamethrin. This finding revealed that ASEO are capable of ameliorating the hepatic oxidative damage induced by deltamethrin.

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Acknowledgements

This work is part of a doctoral thesis by Marwa Ncir. We thank the Ministry of Higher Education and Scientific Research, Tunisia, for their financial support.

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Author notes

  1. Manel Ben Ali and Hanen Sellami have contributed equally to this work.

Authors and Affiliations

  1. Animal Eco-Physiology Laboratory, Sciences Faculty of Sfax, Sfax, Tunisia

    Marwa Ncir, Mohamed Salah Allagui, Abdelfattah El Feki & Mongi Saoudi

  2. Laboratory of Organic Chemistry, Natural Substances Team (LR17ES08), Faculty of Sciences of Sfax, University of Sfax, PB“1171”, PC“3000”, Sfax, Tunisia

    Manel Ben Ali & Noureddine Allouche

  3. Laboratoire de Recherche Toxicologie Microbiologie Environnementale et Santé (LR17ES06), Faculté Des Sciences de Sfax, Université de Sfax, Sfax, Tunisia

    Hanen Sellami

  4. Laboratoire de Traitement et de Valorisation Des Rejets Hydriques (LTVRH), Water Researches and Technologies Center (CERTE), University of Carthage, BP 273-8020, Tourist Route Soliman Nabeul, Tunisia

    Hanen Sellami

  5. Biochemistry Laboratory, CHU Habib Bourguiba of Sfax, Sfax, Tunisia

    Amina Lahyani & Fatma Makni Ayadi

  6. Histopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029, Sfax, Tunisia

    Tahia Boudawara

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  1. Marwa Ncir
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Correspondence to Marwa Ncir.

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Ncir, M., Ben Ali, M., Sellami, H. et al. Protective effects of Allium sativum essential oil rich in disulfides against deltamethrin induced oxidative stress and hepatotoxicity in rats. Food Measure 14, 2667–2675 (2020). https://doi.org/10.1007/s11694-020-00513-1

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