Extracellular matrix (ECM) proteins are highly abundant in the human body and can be found in various tissues, most prominently in connective tissue and basement membrane. For invasive bacterial pathogens, these structures function as physical barriers that block access to underlying tissues. The ability to bind and degrade these barriers is important for the establishment of infections and migration to other body sites. In the oral cavity, the ECM and the basement membrane (BM) are important components of the Junctional epithelium (JE) that closes the gap between the teeth surface and the mucosa. In periodontitis, the JE is breached by invading pathogenic bacteria, particularly strict anaerobic species. In periodontitis, invading microorganisms induce an unregulated and destructive host response through polymicrobial synergism and dysbiosis that attracts immune cells and contributes to the destruction of connective tissue and bone in the periodontal pocket. Colonization of the periodontal pocket is the first step to establish this infection, and binding to ECM is a major advantage in this site. Several species of strict anaerobic bacteria are implicated in acute and chronic periodontitis, and although binding to ECM proteins was studied in these species, few adhesins were identified so far, and the mechanisms involved in adhesion are largely unidentified. This review summarizes the data available on the interaction of strict anaerobic bacteria and components of the ECM.

中文翻译：

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厌氧牙周病原体对细胞外基质蛋白的粘附


细胞外基质（ECM）蛋白在人体内含量丰富，存在于多种组织中，最常见的是结缔组织和基底膜。对于侵入性细菌病原体，这些结构充当物理屏障，阻止其进入底层组织。结合和降解这些屏障的能力对于感染的建立和向身体其他部位的迁移非常重要。在口腔中，ECM 和基底膜 (BM) 是连接上皮 (JE) 的重要组成部分，连接上皮 (JE) 闭合牙齿表面和粘膜之间的间隙。在牙周炎中，乙脑被入侵的致病菌，特别是严格厌氧菌破坏。在牙周炎中，入侵的微生物通过多种微生物的协同作用和菌群失调诱导不受调节的破坏性宿主反应，从而吸引免疫细胞并导致牙周袋中结缔组织和骨骼的破坏。牙周袋的定植是建立这种感染的第一步，与 ECM 的结合是该部位的主要优势。几种严格厌氧细菌与急性和慢性牙周炎有关，尽管在这些物种中研究了与 ECM 蛋白的结合，但迄今为止鉴定出的粘附素很少，并且涉及粘附的机制在很大程度上尚未确定。本综述总结了有关严格厌氧细菌与 ECM 成分相互作用的可用数据。