Abstract

The composition of bacteria in the gastrointestinal tract of piglets is easily affected by environmental changes, particularly during the weaning period. Compound strains of Lactobacillus reuteri and Lactobacillus salivarius were supplemented to piglets during pre- and post-weaning to determine their effects in improving the growth performance and ameliorating the diarrhea rate and stress caused by antioxidation in piglets. A larger number of L. reuteri and L. salivarius colonized the distal segment of the ileum and the total numbers of Lactobacillus spp. and Bifidobacteria were higher in the ileal mucous membrane and cecal lumen with probiotics supplementation. The numbers of antioxidants and immune molecules increased, levels of cortisol and endotoxin reduced, and growth hormone and insulin-like growth factor 1 improved in the plasma following compound bacteria (CL) supplementation. Spearman’s and KEGG analysis of the bacterial operational taxonomic unit and antioxidative and immune indices and metabolic genes indicated that the body growth modulation by CL supplementation could be attributed to optimization of the intestinal bacterial composition; functional strains of L. delbrueckii, L. salivarius, L. formicilis, L. reuteri, and L. mucosae were positively correlated with body antioxidation and immunity derived by CL supplementation. Strains of L. agilis and L. pontis were diverse and negatively correlated with body antioxidation and immunity. Collectively, these results suggest that supplementation with CL could reduce stress and improve the growth performance of piglets during weaning by optimizing the intestinal bacterial composition.

Key points

• The colonization of L. reuteri and L. salivarius in ileal mucous membrane optimize bacterial composition of GIT, mainly some functional strains of Lactobacillus, L. delbrueckii, L. salivarius, L. formicilis, L. reuteri, and L. mucosae.

• The optimized bacterial composition of piglets in both ileal mucous membrane and cecal content improves body growth hormone level, immunity, and antioxidation, which is helpful to defend the stress. These benefits induce to increased growth performance of animal model piglets during weaning.

中文翻译：

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复合乳杆菌 通过断奶仔猪的肠道菌群优化，施用可以减轻压力和身体生长。

摘要

仔猪胃肠道中细菌的组成很容易受到环境变化的影响，尤其是在断奶期间。在断奶前和断奶后向仔猪补充路氏乳杆菌和唾液乳杆菌的复合菌株，以确定它们在改善生长性能，减轻仔猪抗氧化引起的腹泻率和压力方面的作用。较大数量的罗伊氏乳杆菌和唾液乳杆菌定殖回肠的远端段和的总数乳杆菌属。和双歧杆菌补充益生菌后，回肠粘膜和盲肠腔的尿液含量较高。补充复合细菌（CL）后血浆中抗氧化剂和免疫分子的数量增加，皮质醇和内毒素的水平降低，生长激素和胰岛素样生长因子1有所改善。Spearman和KEGG对细菌操作分类单位以及抗氧化和免疫指标以及代谢基因的分析表明，补充CL可以调节人体的生长，这归因于肠道细菌组成的优化。的功能性菌株德氏乳杆菌，唾液乳杆菌，L. formicilis，罗伊氏乳杆菌，和L.粘膜与补充CL产生的身体抗氧化和免疫力呈正相关。敏捷乳酸杆菌和庞氏乳酸杆菌的菌株是多种多样的，并且与人体抗氧化和免疫力呈负相关。总体而言，这些结果表明，补充CL可以通过优化肠道细菌组成来降低断奶期间的压力并改善仔猪的生长性能。

关键点

•回肠乳杆菌和唾液乳杆菌在回肠粘膜上的定殖可优化GIT的细菌组成，主要是乳酸菌，德氏乳杆菌，唾液乳杆菌，胶状乳杆菌，罗伊氏乳杆菌和粘膜乳杆菌的某些功能菌株。

•在回肠粘膜和盲肠中优化仔猪的细菌组成，可改善人体生长激素水平，免疫力和抗氧化性，有助于防御压力。这些益处导致断奶期间动物模型仔猪的生长性能提高。