Compared with conventional drug nanocarriers, multifunctional drug delivery systems exhibited characteristic advantages. In this study, we developed a multifunctional drug delivery system possessing stimuli-responsive drug release and cellular imaging. Amphiphilic polymers, methoxypolyethylene glycol-cystamine-tetraphenylethene (mPEG 1k -SS-TPE), were synthesized by combining methoxypolyethylene glycol (mPEG 1k ) and tetraphenylethene (TPE) using reduction-sensitive disulfide bonds that can be disconnected by high level of inherent glutathione (GSH). Size distribution and morphology of mPEG 1k -SS-TPE micelles were evaluated. Meanwhile, the reduction-sensitivity of mPEG 1k -SS-TPE micelles was surveyed compared with that of mPEG 1k -TPE micelles. Nile Red was encapsulated into mPEG 1k -SS-TPE micelles to visually observe intracellular drug delivery against SW480 cells. Paclitaxel (PTX) was chosen to be loaded into micelles to evaluate the cytotoxicity against HCT116, HT-29, and SW480. Graphical Abstract

中文翻译：

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用于细胞内紫杉醇递送的氧化还原反应性 AIE 胶束

与传统的药物纳米载体相比，多功能药物递送系统表现出特有的优势。在这项研究中，我们开发了一种具有刺激响应性药物释放和细胞成像的多功能给药系统。两亲性聚合物甲氧基聚乙二醇-胱胺-四苯基乙烯 (mPEG 1k -SS-TPE) 是通过甲氧基聚乙二醇 (mPEG 1k ) 和四苯基乙烯 (TPE) 使用还原敏感的二硫键合成的，该二硫键可以通过高水平的固有谷胱甘肽断开。 GSH）。评估了 mPEG 1k -SS-TPE 胶束的尺寸分布和形态。同时考察了mPEG 1k -SS-TPE胶束与mPEG 1k -TPE胶束的还原敏感性。尼罗红被封装到 mPEG 1k -SS-TPE 胶束中，以直观地观察细胞内针对 SW480 细胞的药物递送。选择紫杉醇 (PTX) 装入胶束以评估对 HCT116、HT-29 和 SW480 的细胞毒性。图形概要