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Redox-responsive AIE micelles for intracellular paclitaxel delivery

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Abstract

Compared with conventional drug nanocarriers, multifunctional drug delivery systems exhibited characteristic advantages. In this study, we developed a multifunctional drug delivery system possessing stimuli-responsive drug release and cellular imaging. Amphiphilic polymers, methoxypolyethylene glycol-cystamine-tetraphenylethene (mPEG1k-SS-TPE), were synthesized by combining methoxypolyethylene glycol (mPEG1k) and tetraphenylethene (TPE) using reduction-sensitive disulfide bonds that can be disconnected by high level of inherent glutathione (GSH). Size distribution and morphology of mPEG1k-SS-TPE micelles were evaluated. Meanwhile, the reduction-sensitivity of mPEG1k-SS-TPE micelles was surveyed compared with that of mPEG1k-TPE micelles. Nile Red was encapsulated into mPEG1k-SS-TPE micelles to visually observe intracellular drug delivery against SW480 cells. Paclitaxel (PTX) was chosen to be loaded into micelles to evaluate the cytotoxicity against HCT116, HT-29, and SW480.

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Authors and Affiliations

  1. Department of General Surgery, Binzhou People’s Hospital, Binzhou, 256600, China

    Qiang Wang, Feng Gao & Xianyong Zhou

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  1. Qiang Wang
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  2. Feng Gao
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Correspondence to Qiang Wang.

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Wang, Q., Gao, F. & Zhou, X. Redox-responsive AIE micelles for intracellular paclitaxel delivery. Colloid Polym Sci 298, 1119–1128 (2020). https://doi.org/10.1007/s00396-020-04679-4

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