Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Blood samples were collected from pediatric patients with food allergy (FA). The Th2 response was analyzed by pertinent immunological approaches. An FA murine model was developed to test the role of sCD83 in the regulation of FA response. We found that the serum sCD83 levels were lower in FA patients. A negative correlation was detected between serum sCD83 levels and serum Th2 cytokine levels. The presence of sCD83 suppressed Th2 cell differentiation and antigen-specific Th2 cell activation. sCD83 upregulated the T-bet expression and suppressed the GATA3 expression in CD4⁺ T cells. Administration of sCD83 suppressed experimental FA. Pediatric FA patients have low serum sCD83 levels. Administration of sCD83 can alleviate experimental FA via suppression of aberrant Th2 polarization.

异常 T helper-2 (Th2) 反应在过敏性疾病的发病机制中起关键作用。其潜在机制有待进一步研究。据报道，可溶性 CD83 (sCD83) 具有免疫调节作用。本研究旨在探讨 sCD83 在调节 Th2 极化中的作用。从患有食物过敏 (FA) 的儿科患者身上收集血液样本。通过相关的免疫学方法分析 Th2 反应。开发了 FA 鼠模型以测试 sCD83 在 FA 反应调节中的作用。我们发现 FA 患者的血清 sCD83 水平较低。在血清 sCD83 水平和血清 Th2 细胞因子水平之间检测到负相关。sCD83 的存在抑制了 Th2 细胞分化和抗原特异性 Th2 细胞活化。⁺ T 细胞。sCD83 的管理抑制了实验性 FA。小儿 FA 患者的血清 sCD83 水平较低。sCD83 的给药可以通过抑制异常 Th2 极化来缓解实验性 FA。