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Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses

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Abstract

Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Blood samples were collected from pediatric patients with food allergy (FA). The Th2 response was analyzed by pertinent immunological approaches. An FA murine model was developed to test the role of sCD83 in the regulation of FA response. We found that the serum sCD83 levels were lower in FA patients. A negative correlation was detected between serum sCD83 levels and serum Th2 cytokine levels. The presence of sCD83 suppressed Th2 cell differentiation and antigen-specific Th2 cell activation. sCD83 upregulated the T-bet expression and suppressed the GATA3 expression in CD4+ T cells. Administration of sCD83 suppressed experimental FA. Pediatric FA patients have low serum sCD83 levels. Administration of sCD83 can alleviate experimental FA via suppression of aberrant Th2 polarization.

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Acknowledgments

This study was supported by a research grant from Shenzhen Nanshan District Pioneer Group Research Funds (No. LHTD20180007).

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Authors and Affiliations

  1. Departments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China

    Wenyue Song, Hongfen Li, Bingkun Jia, Zhenxi Wang, Qingsheng Liu, Guangping Yang & Xiaorong Li

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  1. Wenyue Song
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  2. Hongfen Li
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  3. Bingkun Jia
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  7. Xiaorong Li
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Contributions

WS, HL, and BJ performed the experiments, analyzed the research data, and reviewed the manuscript. ZW designed the project, supervised the experiments, and wrote the manuscript. All of the authors reviewed the manuscript.

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Correspondence to Xiaorong Li.

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Song, W., Li, H., Jia, B. et al. Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses. Immunol Res 68, 141–151 (2020). https://doi.org/10.1007/s12026-020-09133-9

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