Abstract—We studied the effect of prenatal stress on the activity of glutathione-bound enzymes in the subcellular fractions of neurons and neuroglia of rat neocortex. The results of the study showed that prenatal stress causes changes in the activity of these enzymes in both neurons and neocortical neuroglia. These changes differ in the subcellular fractions of the studied cell populations. In the nuclei of neurons and neuroglia fraction, the activity of glutathione peroxidase increases. In the cytosol of neurons fraction, the activity of glutathione peroxidase decreases, while in the cytosol of neuroglia it grows. In neuronal mitochondria, the activity of glutathione peroxidase and glutathione transferase increases, while in the neuroglial mitochondria fraction, the activity of glutathione peroxidase decreases. It has been suggested that a change in the activity of these enzymes in the subcellular fractions of neurons and neuroglia is one of the causes for the resistance of the neocortex to the effects of prenatal stress.

中文翻译：

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产前应激对大鼠新皮层神经元和神经胶质细胞亚部分中抗氧化酶活性的影响

摘要—我们研究了产前应激对大鼠新皮层神经元和神经胶质细胞亚细胞部分谷胱甘肽结合酶活性的影响。研究结果表明，产前压力会导致神经元和新皮层神经胶质细胞中这些酶的活性发生变化。这些变化在所研究的细胞群的亚细胞部分中有所不同。在神经元和神经胶质细胞核中，谷胱甘肽过氧化物酶的活性增加。在神经元部分的细胞质中，谷胱甘肽过氧化物酶的活性降低，而在神经胶质的细胞质中，其生长。在神经元线粒体中，谷胱甘肽过氧化物酶和谷胱甘肽转移酶的活性增加，而在神经胶质线粒体部分中，谷胱甘肽过氧化物酶的活性降低。