Abstract—We studied the effect of prenatal stress on the activity of glutathione-bound enzymes in the subcellular fractions of neurons and neuroglia of rat neocortex. The results of the study showed that prenatal stress causes changes in the activity of these enzymes in both neurons and neocortical neuroglia. These changes differ in the subcellular fractions of the studied cell populations. In the nuclei of neurons and neuroglia fraction, the activity of glutathione peroxidase increases. In the cytosol of neurons fraction, the activity of glutathione peroxidase decreases, while in the cytosol of neuroglia it grows. In neuronal mitochondria, the activity of glutathione peroxidase and glutathione transferase increases, while in the neuroglial mitochondria fraction, the activity of glutathione peroxidase decreases. It has been suggested that a change in the activity of these enzymes in the subcellular fractions of neurons and neuroglia is one of the causes for the resistance of the neocortex to the effects of prenatal stress.
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This work was financially supported by the Program of Fundamental Scientific Research of State Academies for 2014–2020 (GP-14, section 65).
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Ethical approval. The study was performed in compliance with the recommendations on ethics of working with animals proposed by Directive 2010/63/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes.
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V’yushina, A.V., Pritvorova, A.V., Semenova, O.G. et al. Influence of Prenatal Stress on the Activity of Antioxidant Enzymes in the Subcellular Fractions of the Neurons and Neuroglia of the Rat Neocortex. Neurochem. J. 14, 187–190 (2020). https://doi.org/10.1134/S1819712420020130
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DOI: https://doi.org/10.1134/S1819712420020130