Abstract

Long-term exposure to stressful conditions is associated with neurochemical changes in the cerebral structures, which ultimately result in mood disorders including, but not limited to, depression and anxiety. Finding an effective way to deal with these conditions has always been of interest to researchers. The goal of this review was to discuss the biochemical pathways and mechanisms restraint/immobilization stress induces depression and anxiety disorders, focusing mainly on oxidative damage and neuroinflammation in the central nervous system (CNS), to gain a better understanding of the mechanisms and possible prevention and treatment. Evidence confirms that stress generates high levels of free radicals and reactive oxygen/nitrogen species and neuroinflammation in the brain regions implicated in the pathophysiology of depression and anxiety.

中文翻译：

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固定化应激诱发的焦虑和抑郁中涉及的神经化学变化：氧化应激和神经炎症的作用。

摘要

长期暴露于压力条件下会导致大脑结构发生神经化学变化，最终导致情绪异常，包括但不限于抑郁和焦虑。寻找一种有效的方法来应对这些情况一直是研究人员的兴趣所在。这篇综述的目的是讨论抑制/固定应激引起抑郁和焦虑症的生化途径和机制，主要集中于中枢神经系统（CNS）的氧化损伤和神经炎症，以更好地了解其机制和可能的预防和治疗。有证据表明，压力会在与抑郁症和焦虑症的病理生理学有关的大脑区域中产生大量自由基和活性氧/氮物种以及神经炎症。