Loading is indispensable for the growth, development, and maintenance of joint tissues, including mandibular condylar cartilage, but excessive loading or reduced host adaptive capacity can considerably damage the temporomandibular joint (TMJ), leading to temporomandibular joint osteoarthritis (TMJ-OA). TMJ-OA, associated with other pathological conditions and aging processes, is a highly degenerative disease affecting the articular cartilage. Many treatment modalities for TMJ-OA have been developed. Traditional clinical treatment includes mainly nonsurgical options, such as occlusal splints. However, non-invasive therapy does not achieve joint tissue repair and regeneration. Growing evidence suggests that low-intensity pulsed ultrasound (LIPUS) accelerates bone fracture healing and regeneration, as well as having extraordinary effects in terms of soft tissue repair and regeneration. The latter have received much attention, and various studies have been performed to evaluate the potential role of LIPUS in tissue regeneration including that applied to articular cartilage. The present article provides an overview of the status of LIPUS stimulation used to prevent the onset and progression of TMJ-OA and enhance the tissue regeneration of mandibular condylar cartilage. The etiology and management of TMJ-OA are explained briefly, animal models of TMJ-OA are described, and the effectiveness of LIPUS on cell metabolism and tissue regeneration in the TMJ is discussed.

负荷对于包括下颌con突软骨在内的关节组织的生长，发育和维持是必不可少的，但是过度负荷或宿主适应能力降低会严重损害颞下颌关节（TMJ），从而导致颞下颌关节骨关节炎（TMJ-OA）。与其他病理状况和衰老过程相关的TMJ-OA是影响关节软骨的高度退化性疾病。已经开发出许多用于TMJ-OA的治疗方式。传统的临床治疗主要包括非手术选择，例如咬合夹板。但是，非侵入性疗法不能实现关节组织的修复和再生。越来越多的证据表明，低强度脉冲超声（LIPUS）可以促进骨折的愈合和再生，以及在软组织修复和再生方面具有非凡的效果。后者受到了广泛的关注，并且已经进行了各种研究以评估LIPUS在组织再生中的潜在作用，包括应用于关节软骨的作用。本文概述了LIPUS刺激的状态，这些刺激用于预防TMJ-OA的发作和进展并增强下颌con突软骨的组织再生。简要解释了TMJ-OA的病因和治疗，描述了TMJ-OA的动物模型，并讨论了LIPUS对TMJ中细胞代谢和组织再生的有效性。已经进行了各种研究来评估LIPUS在组织再生中的潜在作用，包括应用于关节软骨的作用。本文概述了LIPUS刺激的状态，这些刺激用于预防TMJ-OA的发作和进展并增强下颌con突软骨的组织再生。简要解释了TMJ-OA的病因和治疗，描述了TMJ-OA的动物模型，并讨论了LIPUS对TMJ中细胞代谢和组织再生的有效性。已经进行了各种研究来评估LIPUS在组织再生中的潜在作用，包括应用于关节软骨的作用。本文概述了LIPUS刺激的状态，这些刺激用于预防TMJ-OA的发作和进展并增强下颌con突软骨的组织再生。简要解释了TMJ-OA的病因和治疗，描述了TMJ-OA的动物模型，并讨论了LIPUS对TMJ中细胞代谢和组织再生的有效性。