Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); however, its role in disease progression is unclear. In a new study by Muto et al., MDS stem cells sparked with TRAF6-activated innate immune signaling were found to outcompete normal counterparts only when fueled by environmental inflammatory stimuli. Non-canonical NF-κB signaling is implicated in inflammatory synergy and MDS progression.

中文翻译：

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哪里有烟，哪里就有火：炎症驱动MDS。

慢性炎症与骨髓增生异常综合症（MDS）有关。但是，其在疾病进展中的作用尚不清楚。在Muto等人的一项新研究中。研究发现，只有在受到环境炎症刺激的情况下，用TRAF6激活的先天免疫信号激发的MDS干细胞才能胜过正常对手。非经典的NF-κB信号传导与炎症协同作用和MDS进展有关。