Trends in Immunology
Volume 41, Issue 7, July 2020, Pages 558-560
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Special Issue: Molecular Mechanisms of Immunity
Where There’s Smoke, There’s Fire: Inflammation Drives MDS

https://doi.org/10.1016/j.it.2020.05.007Get rights and content

Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); however, its role in disease progression is unclear. In a new study by Muto et al., MDS stem cells sparked with TRAF6-activated innate immune signaling were found to outcompete normal counterparts only when fueled by environmental inflammatory stimuli. Non-canonical NF-κB signaling is implicated in inflammatory synergy and MDS progression.

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Acknowledgments

The laboratory of M.A.G. is supported by the National Institutes of Health (grants DK092883, AG036695, CA183252, CA237291, and CA236972) and the Edward P. Evans Foundation.

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