Streptococcus pyogenes is a species of Gram-positive bacteria. It is also known as Group A Streptococcus (GAS) that causes pathogenesis to humans only. The GAS infection has several manifestations including invasive illness. Current research has linked the molecular modes of GAS virulence with substantial sequencing determinations for the isolation of genomes. These advances help to comprehend the molecular evolution resulting in the pandemic strains. Thus, it is indispensable to reconsider the philosophy that involves GAS pathogenesis. The recent investigations involve studying GAS in the nasopharynx and its capability to cause infection or asymptomatically reside in the host. These advances have been discussed in this article with an emphasis on the natural history of GAS and the evolutionary change in the pandemic strains. In addition, this review describes the unique functions for major pathogenicity determinants to comprehend their physiological effects.

中文翻译：

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剖析化脓性链球菌与人类的相互作用

化脓性链球菌是一种革兰氏阳性菌。它也被称为 A 组链球菌 (GAS)，仅对人类致病。GAS 感染有多种表现，包括侵袭性疾病。目前的研究已将 GAS 毒力的分子模式与用于分离基因组的大量测序测定联系起来。这些进展有助于理解导致大流行毒株的分子进化。因此，重新考虑涉及 GAS 发病机制的哲学是必不可少的。最近的调查涉及研究鼻咽中的 GAS 及其引起感染或无症状存在于宿主中的能力。本文讨论了这些进展，重点是 GAS 的自然历史和大流行毒株的进化变化。此外，