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Dissecting Streptococcus pyogenes interaction with human

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Abstract

Streptococcus pyogenes is a species of Gram-positive bacteria. It is also known as Group A Streptococcus (GAS) that causes pathogenesis to humans only. The GAS infection has several manifestations including invasive illness. Current research has linked the molecular modes of GAS virulence with substantial sequencing determinations for the isolation of genomes. These advances help to comprehend the molecular evolution resulting in the pandemic strains. Thus, it is indispensable to reconsider the philosophy that involves GAS pathogenesis. The recent investigations involve studying GAS in the nasopharynx and its capability to cause infection or asymptomatically reside in the host. These advances have been discussed in this article with an emphasis on the natural history of GAS and the evolutionary change in the pandemic strains. In addition, this review describes the unique functions for major pathogenicity determinants to comprehend their physiological effects.

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Authors and Affiliations

  1. Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan

    Munazza Ijaz & Saba Shamim

  2. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

    Fuad Ameen

  3. City University College of Ajman, 18484, Ajman, United Arab Emirates

    Yaseen Abd Alfoteih

  4. Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia

    Wafa A. Alshehri

  5. Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, 54000, Pakistan

    Ghulam Murtaza

Authors
  1. Munazza Ijaz
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  2. Fuad Ameen
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  3. Yaseen Abd Alfoteih
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  4. Saba Shamim
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  5. Wafa A. Alshehri
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  6. Ghulam Murtaza
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Corresponding authors

Correspondence to Saba Shamim or Ghulam Murtaza.

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Communicated by Erko Stackebrandt.

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Ijaz, M., Ameen, F., Alfoteih, Y.A. et al. Dissecting Streptococcus pyogenes interaction with human. Arch Microbiol 202, 2023–2032 (2020). https://doi.org/10.1007/s00203-020-01932-w

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  • DOI: https://doi.org/10.1007/s00203-020-01932-w

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