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The Role of Endotheliocytes of Liver Sinusoid Capillaries in the Pathogenesis of Disorders in the Vascular-Platelet Link of Hemostasis in the Acute Period of Traumatic Brain Injury
Cell and Tissue Biology Pub Date : 2020-03-12 , DOI: 10.1134/s1990519x20010046 G. A. Boyarinov , Ye. I. Yakovleva , A. V. Deryugina , O. D. Solovyeva , L. V. Boyarinova , A. V. Polozova , Ye. V. Moshnina , L. A. Shchegolkov
中文翻译:
肝窦窦毛细血管内皮细胞在创伤性脑损伤急性期止血的血管-血小板连接障碍的发病机理中的作用
更新日期:2020-03-12
Cell and Tissue Biology Pub Date : 2020-03-12 , DOI: 10.1134/s1990519x20010046 G. A. Boyarinov , Ye. I. Yakovleva , A. V. Deryugina , O. D. Solovyeva , L. V. Boyarinova , A. V. Polozova , Ye. V. Moshnina , L. A. Shchegolkov
Abstract—
In rats subjected to traumatic brain injury (TBI), at the stage of acute development of traumatic disease, the platelet number, ultrastructural changes in liver sinusoid hemocapillaries (SCs), and microcirculation disorders in their lumen were studied. The results of the study showed that, in local brain injury, on the third day of post-traumatic period, thrombocytopenia, expressed lesions of liver SCs, and intrasinusoid microcirculation disorders, which are aggravated on the seventh day post injury, are detected. On the 12th day after TBI, the sinusoid endothelium is detected to be of usual appearance, but yet areas of its swelling and edema occur. In 79% of sinusoid hemocapillaries, the blood flow is recovered, while in 21% macro- and micro aggregates of erythrocytes, bubbles, cellular detritus, and platelets are detected. Analyzing the obtained data, we can conclude that the detected lesions of liver SC endotheliocytes in the acute period of TBI make it possible to consider them one of the key, and earliest, links of pathogenesis of the vascular–platelet link of hemostasis.中文翻译:
肝窦窦毛细血管内皮细胞在创伤性脑损伤急性期止血的血管-血小板连接障碍的发病机理中的作用