Abstract—

In rats subjected to traumatic brain injury (TBI), at the stage of acute development of traumatic disease, the platelet number, ultrastructural changes in liver sinusoid hemocapillaries (SCs), and microcirculation disorders in their lumen were studied. The results of the study showed that, in local brain injury, on the third day of post-traumatic period, thrombocytopenia, expressed lesions of liver SCs, and intrasinusoid microcirculation disorders, which are aggravated on the seventh day post injury, are detected. On the 12th day after TBI, the sinusoid endothelium is detected to be of usual appearance, but yet areas of its swelling and edema occur. In 79% of sinusoid hemocapillaries, the blood flow is recovered, while in 21% macro- and micro aggregates of erythrocytes, bubbles, cellular detritus, and platelets are detected. Analyzing the obtained data, we can conclude that the detected lesions of liver SC endotheliocytes in the acute period of TBI make it possible to consider them one of the key, and earliest, links of pathogenesis of the vascular–platelet link of hemostasis.

中文翻译：

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肝窦窦毛细血管内皮细胞在创伤性脑损伤急性期止血的血管-血小板连接障碍的发病机理中的作用

摘要-

在遭受外伤性脑损伤（TBI）的大鼠中，在外伤性疾病的急性发展阶段，研究了其血小板数量，肝窦毛细血管（SCs）的超微结构变化以及其管腔中的微循环障碍。研究结果表明，在局部脑损伤中，在创伤后第三天发现了血小板减少症，肝脏SC的表达损伤和窦内微循环障碍，这些损伤在受伤后第七天加剧了。在TBI后的第12天，检测到窦状内皮具有通常的外观，但仍出现其肿胀和水肿的区域。在79％的窦状毛细血管中，血流得以恢复，而在21％的红细胞，泡沫，细胞碎屑和血小板中，则有宏观和微观的聚集。