The abuse of antibiotics in therapy has lead to the development of resistance in the target organisms. The failure of presented antibiotics to control infections makes it essential to discover option to presently available drugs. Quorum sensing (QS) is a used by many bacteria to regulate gene expression in accordance with population density through the use of signal molecules or autoinducers. The QS is used by Bacteria populations to communicate and coordinate their group interactions, which is applied by pathogens in infection processes. The QS pathways in bacteria are composed of several parts, including bacteria populations, signal molecules, protein activators and target genes. The pathogenicity in numerous bacteria is regulated by QS signaling systems. The QS inhibition system may cause the reduction of virulence and defense against bacterial infections. The QS is the main regulator of virulence and biofilm formation in Pseudomonas aeruginosa and other relevant bacteria. In P. aeruginosa, the expression of many virulence factors appears to be controlled by QS. So, according to the role of this mechanism in the regulation and production of many virulence factors, the function of QS is required for P. aeruginosa to cause disease and infection. In this article, we discussed the QS mechanism in gram-negative and gram-positive bacteria with a closer look at the P. aeruginosa. A variety of plants showed their effects on P. aeruginosa virulence. Extract of various plants control the regulatory QS genes and factors with marginal effects on bacterial growth. The quorum-quenching (QQ) mechanisms are unrelated to static or cidal effects. In fact, anti-QS have already shown promise in the battle against P. aeruginosa infections.

中文翻译：

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群体感应抑制剂对铜绿假单胞菌的作用

治疗中滥用抗生素导致靶标生物产生耐药性。现有的抗生素无法控制感染，因此必须找到目前可用药物的选择。群体感应 (QS) 被许多细菌用来通过使用信号分子或自诱导剂根据种群密度调节基因表达。QS 被细菌种群用来交流和协调它们的群体相互作用，病原体在感染过程中应用这种相互作用。细菌中的 QS 通路由几部分组成，包括细菌种群、信号分子、蛋白质激活剂和靶基因。许多细菌的致病性由 QS 信号系统调节。QS 抑制系统可能导致毒力降低和对细菌感染的防御。QS 是铜绿假单胞菌和其他相关细菌毒力和生物膜形成的主要调节因子。在铜绿假单胞菌中，许多毒力因子的表达似乎受 QS 控制。因此，根据该机制在许多毒力因子的调节和产生中的作用，铜绿假单胞菌引起疾病和感染需要QS的功能。在本文中，我们通过仔细观察铜绿假单胞菌，讨论了革兰氏阴性和革兰氏阳性细菌的 QS 机制。多种植物显示了它们对铜绿假单胞菌毒力的影响。各种植物的提取物控制对细菌生长具有边际影响的调节性 QS 基因和因子。群体淬灭 (QQ) 机制与静态或杀灭效应无关。事实上，抗 QS 已经在对抗铜绿假单胞菌感染的斗争中显示出希望。