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Effect of Quorum Sensing Inhibitor Agents against Pseudomonas aeruginosa

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Abstract

The abuse of antibiotics in therapy has lead to the development of resistance in the target organisms. The failure of presented antibiotics to control infections makes it essential to discover option to presently available drugs. Quorum sensing (QS) is a used by many bacteria to regulate gene expression in accordance with population density through the use of signal molecules or autoinducers. The QS is used by Bacteria populations to communicate and coordinate their group interactions, which is applied by pathogens in infection processes. The QS pathways in bacteria are composed of several parts, including bacteria populations, signal molecules, protein activators and target genes. The pathogenicity in numerous bacteria is regulated by QS signaling systems. The QS inhibition system may cause the reduction of virulence and defense against bacterial infections. The QS is the main regulator of virulence and biofilm formation in Pseudomonas aeruginosa and other relevant bacteria. In P. aeruginosa, the expression of many virulence factors appears to be controlled by QS. So, according to the role of this mechanism in the regulation and production of many virulence factors, the function of QS is required for P. aeruginosa to cause disease and infection. In this article, we discussed the QS mechanism in gram-negative and gram-positive bacteria with a closer look at the P. aeruginosa. A variety of plants showed their effects on P. aeruginosa virulence. Extract of various plants control the regulatory QS genes and factors with marginal effects on bacterial growth. The quorum-quenching (QQ) mechanisms are unrelated to static or cidal effects. In fact, anti-QS have already shown promise in the battle against P. aeruginosa infections.

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REFERENCES

  1. Centers for Disease Control and Prevention, H.I.P. National Nosocomial Infections Surveillance (NNIS) Report, data summary from January 1992–June 2004, issued October 2004: a report from the NNIS System, Am. J. Infection Control., 2004, vol. 32, pp. 470–485.

  2. Manefield, M., Rasmussen, T.B., Henzter, M., Andersen, J.B., Steinberg, P., Kjelleberg, S., and Givskov, M., Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover, Microbiology, 2002, vol. 148, pp. 1119–1127.

    Article  CAS  PubMed  Google Scholar 

  3. Cumberbatch, A., Characterization of the Anti-Quorum Sensing Activity Exhibited by Marine Macroalgae of South Florida, Miami: Florida International University, Department of Biological Sciences, 2002.

    Google Scholar 

  4. Bjarnsholt, T., Jensen, P.O., Rasmussen, T.B., Christophersen, L., Calum, H., Hentzer, M.H., Hougen, P., Rygaard, J., Moser, C., Eberl, L., Hoiby, N., and Givskov, M., Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections, Microbiology, 2005, vol. 151, pp. 3873–3880.

    Article  CAS  PubMed  Google Scholar 

  5. Gao, M., Teplitski, M., Robinson, J.B., and Bauer, W.D., Production of substances by Medicago truncatula that affect bacterial quorum sensing, Mol. Plant Microbe Interact., 2003, vol. 16, pp. 827–834.

    Article  CAS  PubMed  Google Scholar 

  6. Yoon, Y. and Sofos, J.N., Absence of association of autoinducer-2-based quorum sensing with heat and acid resistance of Salmonella,J. Food Sci., 2010, vol. 75, pp. 444–448.

    Article  CAS  Google Scholar 

  7. Adonizio, A.L.K., Downum, B.C., Bennett, and Mathee, K., Antiquorum sensing activity of medicinal plants in southern Florida, J. Ethnopharmacol., 2006, vol. 103, pp. 427–435.

    Article  Google Scholar 

  8. Bauer, W.D. and Mathesius, U., Plant responses to bacterial quorum sensing signals, Curr. Opin. Plant Biol., 2004, vol. 7, pp. 429–433.

    Article  CAS  PubMed  Google Scholar 

  9. Carson, C.F., Riley, T.V., and Cookson, B.D., Efficacy and safety of tea tree oil as a topical antimicrobial agent, J. Hosp. Infect., 1998, vol. 40, pp. 175–178.

    Article  CAS  PubMed  Google Scholar 

  10. Carson, C.F. and Riley, T.V., Antimicrobial activity of the major components of the essential oil of Melaleuca alternifolia,J. Appl. Bacteriol., 1995, vol. 78, pp. 264–269.

    Article  CAS  PubMed  Google Scholar 

  11. Costerton, J.W., Lewandowski, Z., Caldwell, D.E., Korber, D.R., and Lappin-Scott, H.M., Microbial biofilms, Ann. Rev. Microbiol., 1995, vol. 49, pp. 711–745.

    Article  CAS  Google Scholar 

  12. Bauer, W.D. and Tepletski, M., Can plants manipulate bacterial quorum sensing?, Aust. J. Plant Physiol., 2001, vol. 28, pp. 913–921.

    CAS  Google Scholar 

  13. Nealson, K.H., Platt, T., and Hastings, J.W., Cellular control of the synthesis and activity of the bacterial luminescent system, J. Bacteriol., 1970, vol. 104, pp. 313–322.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Hastings, J.W. and Greenberg, E.P., Quorum sensing: The explanation of a curious phenomenon reveals a common characteristic of bacteria, J. Bacteriol., 1999, vol. 181, pp. 2667–2668.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Schauder, S. and Bassler, B.L., The languages of bacteria, Genes Dev., 2001, vol. 15, pp. 1468–1480.

    Article  CAS  PubMed  Google Scholar 

  16. McClean, R.J.C., Pierson, I., Leland, S., and Fuqua, C., A simple screening protocol for the identification of quorum signal antagonists, J. Microbiol Methods, 2004, vol. 58, pp. 351–360.

    Article  CAS  Google Scholar 

  17. Rasmussen, T.B., Manefield, M., Andersen, J.B., Eberl, L., Anthoni, U., Christophersen, C., Steinberg, P., Kjelleberg, S., and Givskov, M., How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1, Microbiology, 2000, vol. 146, pp. 3237–3244.

    Article  CAS  PubMed  Google Scholar 

  18. Henke, J.M. and Bassler, B.L., Bacterial social engagements, Trends Cell Biol., 2004, vol. 14, pp. 648–656.

    Article  CAS  PubMed  Google Scholar 

  19. Bassler, B.L., Wright, M., Showalter, R.E., and Silverman, M.R., Intercellular signalling in Vibrio harveyi: Sequence and function of genes regulating expression of luminescence, Mol. Microbiol., 1993, vol. 9, pp. 773–786.

    Article  CAS  PubMed  Google Scholar 

  20. Stevens, A. and Greenberg, E., Quorum sensing in Vibrio fischeri: Essential elements for activation of the luminescence genes, J. Bacteriol., 1997, vol. 179, pp. 557–562.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Fuqua, C. and Greenberg, E.P., Self perception in bacteria: Quorum sensing with acylated homoserine lactones, Curr. Opin. Microbiol., 1998, vol. 1, pp. 183–189.

    Article  CAS  PubMed  Google Scholar 

  22. Whitehead N.A., Barnard A.M., Slater H., Simpson N.J., Salmond G.P. Quorum-sensing in gram-negative bacteria, FEMS Microbiol. Rev., 2001, vol. 25, pp. 365–404.

    Article  CAS  PubMed  Google Scholar 

  23. Cao, M., Feng, Y., Wang, C., Zheng, F., Li, M., Liao, H., Mao, Y., Pan, X., Wang, J., Hu, D., Hu, F., Tang, J., Functional definition of LuxS, an autoinducer-2 (AI-2) synthase and its role in full virulence of Streptococcus suis serotype 2, J. Microbiol., 2011, vol. 49, pp. 1000–1011.

    Article  CAS  PubMed  Google Scholar 

  24. Halliday, N.M., Hardie, K.R., Williams, P., Winzer, K., and Barrett, D.A., Quantitative liquid chromatography-tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli,Anal. Biochem., 2010, vol. 403, pp. 1–2.

    Article  CAS  Google Scholar 

  25. Hagen, S.J., Son, M., Weiss, J.T., and Young, J.H., Bacterium in a box: Sensing of quorum and environment by the LuxI/LuxR gene regulatory circuit, J. Biol. Phys., 2010, vol. 36, pp. 317–327.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Sperandio, V. and Sdi, A., Sensing of acyl-homoserine lactones by enterohemorrhagic E. coli (EHEC) serotype O157:H7 in the bovine rumen, Gut Microbes, 2010, vol. 1, pp. 432–435.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Pesci, E., Pearson, J., Seed, P., and Iglewski, B., Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa,J. Bacteriol., 1997, vol. 179, pp. 3127–3132.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Surette, M.G. and Bassler, B.L., Quorum sensing in Escherichia coli and Salmonella typhimurium,Proc. Natl. Acad. Sci. U. S. A., 1998, vol. 95, pp. 7046–7050.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Rodelas, B., Lithgow, J.K., Wisniewski-Dye, F., Hardman, A., Wilkinson, A., Economou, A., Williams, P., and Downie, J.A., Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae, J. Bacteriol., 1999, vol. 181, pp. 3816–3823.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Von Bodman, S.B., Bauer, W.D., and Coplin, D.L., Quorum sensing in plant-pathogenic bacteria, Ann. Rev. Phytopathol., 2003, vol. 41, pp. 455–482.

    Article  CAS  Google Scholar 

  31. Fuqua, C. and Greenberg, E., Listening in on bacteria: Acyl-homoserine lactone signaling, Nat. Rev. Mol. Cell. Biol., 2002, vol. 3, pp. 685–695.

    Article  CAS  PubMed  Google Scholar 

  32. Fuqua, W.C., Winans, S.C., and Greenberg, E.P., Quorum sensing in bacteria: The LuxR–LuxI family of cell density-responsive transcriptional regulators, J. Bacteriol., 1994, vol. 176, pp. 269–275.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Dong, Y.H., Wang, L.H., Xu, J.L., Zhang, H.B., Zhang, X.F., and Zhang, L.H., Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase, Nature, 2001, vol. 411, pp. 813–817.

    Article  CAS  PubMed  Google Scholar 

  34. Cha, C.G.P., Chen, Y.C., Shaw, P.D., and Farrand, S.K., Production of acyl-homoserine lactone quorum-sensing signals by gram-negative plant-associated bacteria, Mol. Plant Microbe Interact., 1998, vol. 11, pp. 1119–1129.

    Article  CAS  PubMed  Google Scholar 

  35. Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, J. Clin. Invest., 2003, vol. 112, pp. 1460–1465.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum-sensing systems and virulence, Curr. Opin. Microbiol., 2003, vol. 6, pp. 56–60.

    Article  CAS  PubMed  Google Scholar 

  37. Debler, E.W., Kaufmann, G.F., Kirchdoerfer, R.N., Mee, J.M., Janda, K.D., and Wilson, I.A., Crystal structures of a quorum-quenching antibody, J. Mol. Biol., 2007, vol. 368, pp. 1392–1402.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Hoang, T.T., Sullivan, S.A., Cusick, J.K., and Schweizer, H.P., beta-Ketoacyl acyl carrier protein reductase (FabG) activity of the fatty acid biosynthetic pathway is a determining factor of 3-oxo-homoserine lactone acyl chain lengths, Microbiology, 2002, vol. 148, pp. 3849–3856.

    Article  CAS  PubMed  Google Scholar 

  39. Albus, A., Pesci, E., Runyen-Janecky, L., West, S., and Iglewski, B., Vfr controls quorum sensing in Pseudomonas aeruginosa,J. Bacteriol., 1997, vol. 179, pp. 3928–3935.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Dong, Y.H. and Zhang, L.H., Quorum sensing and quorum-quenching enzymes, J. Microbiol., 2005, vol. 43, pp. 101–109.

    CAS  PubMed  Google Scholar 

  41. Schuster, M. and Greenberg, E.P., A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa,Int. J. Med. Microbiol., 2006, vol. 296, pp. 73–81.

    Article  CAS  PubMed  Google Scholar 

  42. Hentzer, M. and Givskov, M., Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, J. Clin. Invest., 2003, vol. 112, pp. 1300–1307.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Whitehead, N.A., Welch, M., and Salmond, G.P.C., Silencing the majority, Nat. Biotechnol., 2001, vol. 19, pp. 735–736.

    Article  CAS  PubMed  Google Scholar 

  44. Bodey, G.P., Bolivar, R., Fainstein, V., and Jadeja, L., Infections caused by Pseudomonas aeruginosa,Rev. Infect. Dis., 1983, vol. 5, pp. 279–313.

    Article  CAS  PubMed  Google Scholar 

  45. Vasil, M.L., Pseudomonas aeruginosa: Biology, mechanisms of virulence, epidemiology, J. Pediatrics, 1986, vol. 108, pp. 800–805.

    Article  CAS  Google Scholar 

  46. Meyer, J., Neely, A., Stintzi, A., Georges, C., and Holder, I., Pyoverdin is essential for virulence of Pseudomonas aeruginosa,Infect. Immun., 1996, vol. 64, pp. 518–523.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Cox, C.D. and Adams, P., Siderophore activity of pyoverdin for Pseudomonas aeruginosa,Infect. Immun., 1985, vol. 48, pp. 130–138.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Choi, Y., Park, H.Y., Park, S.J., Kim, S.K., Ha, C., Im, S.J., and Lee, J.H., Erratum to: Growth phase-differential quorum sensing regulation of anthranilate metabolism in Pseudomonas aeruginosa,Mol. Cells, 2011, vol. 32, p. 597.

    Article  CAS  PubMed Central  Google Scholar 

  49. Kessler, E., Beta-lytic endopeptidases, Methods Enzymol., 1995, vol. 248, pp. 740–756.

    Article  CAS  PubMed  Google Scholar 

  50. Krcmery, V., Koprnova, J., Gogova, M., Grey, E., and Korcova, J., Pseudomonas aeruginosa bacteraemia in cancer patients, J. Infect., 2006, vol. 52, pp. 461–463.

    Article  PubMed  Google Scholar 

  51. Meynard J.L., Barbut F., Guiguet M., et al., Pseudomonas aeruginosa infection in human immunodeficiency virus infected patients. J. Infect., 1999, vol. 38, pp. 176–181.

    Article  CAS  PubMed  Google Scholar 

  52. Foca, M.D., Pseudomonas aeruginosa infections in the neonatal intensive care unit, Semin. Perinatol., 2002, vol. 26, pp. 332–339.

    Article  PubMed  Google Scholar 

  53. Robertson, D.M., Petroll, W.M., Jester, J.V., and Cavanagh, H.D., Current concepts: Contact lens related Pseudomonas keratitis, Contact Lens Anterior Eye, 2007, vol. 30, pp. 94–107.

    Article  PubMed  Google Scholar 

  54. Roland, P.S., Chronic suppurative otitis media: A clinical overview, Ear Nose Throat J., 2002, vol. 81, pp. 8–10.

    Article  PubMed  Google Scholar 

  55. Mowat, E., Paterson, S., Fothergill, J.L., Wright, E.A., Ledson, M.J., Walshaw, M.J., Brockhurst, M.A., Winstanley, C., Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections, Am. J. Respir. Crit. Care Med., 2011, vol. 183, pp. 1674–1679.

    Article  PubMed  Google Scholar 

  56. Shi, M., Li, Y., Wang, Y., Huang, J., Huang, X., and Xu, Y., Regulation of GacA on two phz gene clusters and quorum sensing in Pseudomonas sp. M18, Wei Sheng Wu Xue Bao, 2009, vol. 49, pp. 1306–1316.

    CAS  PubMed  Google Scholar 

  57. Pustelny, C., Albers, A., Buldt-Karentzopoulos, K., Parschat, K., Chhabra, S.R., Camara, M., Williams, P., and Fetzner, S., Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa,Chem. Biol., 2009, vol. 16, pp. 1259–1267.

    Article  CAS  PubMed  Google Scholar 

  58. Cotar, A.I., Chifiriuc, M.C., Dinu, S., Pelinescu, D., Banu, O., and Lazar, V., Quantitative real-time PCR study of the influence of probiotic culture soluble fraction on the expression of Pseudomonas aeruginosa quorum sensing genes, Roum. Arch. Microbiol. Immunol., 2010, vol. 69, pp. 213–223.

    CAS  PubMed  Google Scholar 

  59. Tsai, M.J., Teng, C.J., Teng, R.J., Lee, P.I., and Chang, M.H., Necrotizing bowel lesions complicated by Pseudomonas septicaemia in previously healthy infants, Eur J. Pediatrics, 1996, vol. 155, pp. 216–218.

    Article  CAS  Google Scholar 

  60. Nicolle, L.E., Resistant pathogens in urinary tract infections, J. Am. Geriatrics Soc., 2002, vol. 50, pp. 230–235.

    Article  Google Scholar 

  61. Sapico, F.L. and Montgomerie, J.Z., Vertebral osteomyelitis, Infect. Dis. Clin. North Am., 1990, vol. 4, pp. 539–550.

    CAS  PubMed  Google Scholar 

  62. Yu, Y., Cheng, A.S., Wang, L., Dunne, W.M., and Bayliss, S.J., Hot tub folliculitis or hot hand-foot syndrome caused by Pseudomonas aeruginosa,J. Am. Acad. Dermatol., 2007, vol. 57, pp. 596–600.

    Article  PubMed  Google Scholar 

  63. Adonizio, A., Kong, K.F., and Pritt, K., Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by south Florida plant extracts, Antimicrob. Agents Chemother., 2008, vol. 52, pp. 198–203.

    Article  CAS  PubMed  Google Scholar 

  64. Hooper, D.C., Mode of action of fluoroquinolones, Drugs, 1999, vol. 58, pp. 6–10.

    Article  CAS  PubMed  Google Scholar 

  65. Flanders, S.A., Collard, H.R., and Saint, S., Nosocomial pneumonia: State of the science, Am. J. Infect. Control., 2006, vol. 34, pp. 84–93.

    Article  PubMed  Google Scholar 

  66. Donlan, R.M. and Costerton, J.W., Biofilms: Survival mechanisms of clinically relevant microorganisms, Clin. Microbiol. Rev., 2002, vol. 15, pp. 167–193.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Davies, D.G., Parsek, M.R., Pearson, J.P., Iglewski, B.H., Costerton, J.W., and Greenberg, E.P., The involvement of cell-to-cell signals in the development of a bacterial biofilm, Science, 1998, vol. 280, pp. 295–298.

    Article  CAS  PubMed  Google Scholar 

  68. Hoyle, B. and Costerton, J.W., Bacterial resistance to antibiotics: The role of biofilms, Progr. Drug Res., 1991, vol. 37, pp. 91–105.

    CAS  Google Scholar 

  69. Lyczak, J.B., Cannon, C.L., and Pier, G.B., Lung infections associated with cystic fibrosis, Clin. Microbiol. Rev., 2002, vol. 15, pp. 194–222.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Lazar, V. and Chifiriuc, M.C. Architecture and physiology of microbial biofilms, Roum. Arch. Microbiol. Immunol., 2010, vol. 69, pp. 95–107.

    CAS  PubMed  Google Scholar 

  71. Martinez, L.R. and Fries, B.C., Fungal biofilms: Relevance in the setting of human disease, Curr. Fungal Infect. Rep., 2010, vol. 4, pp. 266–275.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Sintim, H.O., Smith, J.A., Wang, J., Nakayama, S., and Yan, L., Paradigm shift in discovering next-generation anti-infective agents: Targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules, Future Med. Chem., 2010, vol. 2, pp. 1005–1035.

    Article  CAS  PubMed  Google Scholar 

  73. Hentzer, M. and Givskov, M., Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, J. Clin. Invest., 2003, vol. 112, pp. 1300–1307.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, J. Clin. Invest., 2003, vol. 112, pp. 1460–1465.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. McKnight, S.L., Iglewski, B.H., and Pesci, E.C., The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa.J. Bacteriol., 2000, vol. 182, pp. 2702–2708.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Espin, J.C., Garcia-Conesa, M.T., and Tomas-Barberan, F.A., Nutraceuticals: Facts and fiction, Phytochemistry, 2007, vol. 68, pp. 2986–3008.

    Article  CAS  PubMed  Google Scholar 

  77. Pesci, E.C., Milbank, J.B.J., Pearson, J.P., McKnight, S., Kende, A.S., Greenberg, E.P., and Iglewski, B.H., Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa,Proc. Natl. Acad. Sci. U. S. A., 1999, vol. 96, pp. 11 229–11 234.

    Article  Google Scholar 

  78. Reimmann, C., Beyeler, M., Latifi, A., Winteler, H., Foglino, M., Lazdunski, A., and Haas, D., The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase, Mol. Microbiol., 1997, vol. 24, pp. 309–319.

    Article  CAS  PubMed  Google Scholar 

  79. Throup, J., Winson, M.K., Bainton, N.J., Bycroft, B.W., Williams, P., and Stewart, G.S.A.B., Signalling in bacteria beyond bioluminescence, in Bioluminescence and Chemiluminescence: Fundamentals and Applied Aspects, Campbell, A., Kricka, L., and Stanley, P., Eds., Chichester: Wiley, 1995.

    Google Scholar 

  80. Calfee, M.W., Coleman, J.P., and Pesci, E.C., Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa,Proc. Natl. Acad. Sci. U. S. A., 2001, vol. 98, pp. 11 633–11 637.

    Article  Google Scholar 

  81. Holden, M.T.G., Chhabra, S.R., de Nys, R., Stead, P., Balnton, N.J., Hill, P.J., Manefield, M., Kumar, N., Maurice, L., England, D., Rice, S., Glvskov, M., Salmond, G.P.C., Stewart, G.S.A.B., Bycroft, B.W., Kjelleberg, S., and Williams, P., Quorum-sensing cross talk: Isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria, Mol. Microbiol., 1999, vol. 33, pp. 1254–1266.

    Article  CAS  PubMed  Google Scholar 

  82. Li, Q., Ni, H., Meng, S., He, Y., Yu, Z., and Li, L., Suppressing Erwinia carotovora pathogenicity by projecting N-acyl homoserine lactonase onto the surface of Pseudomonas putida cells, J. Microbiol. Biotechnol., 2011, vol. 21, pp. 1330–1335.

    Article  CAS  PubMed  Google Scholar 

  83. Van Delden, C. and Iglewski, B.H., Cell-to-cell signaling and Pseudomonas aeruginosa infections, Emerg. Infect. Dis., 1998, vol. 4, pp. 551–560.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Gambello, M.J. and Iglewski, B.H., Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression, J. Bacteriol., 1991, vol. 179, pp. 3000–3009.

    Article  Google Scholar 

  85. Pritt, K., McPherson, C., and Ohman, D., Posttranslational control of the algT (algU)-encoded sigma22 for expression of the alginate regulon in Pseudomonas aeruginosa and localization of its antagonist proteins MucA and MucB (AlgN), J. Bacteriol., 1997, vol. 179, pp. 3711–3720.

    Article  Google Scholar 

  86. Hentzer, M., Reidel, K., and Rasmussen, T.B., Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound, Microbiology, 2002, vol. 148, pp. 87–102.

    Article  CAS  PubMed  Google Scholar 

  87. Wu, H., Song, Z., Hentzer, M., Andersen, J.B., Molin, S., Givskov, M., and Hoiby, N., Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice, J. Antimicrob. Chemother., 2004, vol. 53, pp. 1054–1061.

    Article  CAS  PubMed  Google Scholar 

  88. Manefield, M., de Nys, R., Kumar, N., Read, R., Givskov, M., Steinberg, P., and Kjelleberg, S., Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology, 1999, vol. 145, pp. 283–291.

    Article  CAS  PubMed  Google Scholar 

  89. Manefield, M., Rasmussen, T.B., Henzter, M., Andersen, J.B., Steinberg, P., Kjelleberg, S., and Givskov, M., Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover, Microbiology, 2002, vol. 148, pp. 1119–1127.

    Article  CAS  PubMed  Google Scholar 

  90. Ren, D., Zuo, R., and Wood, T.K., Quorum-sensing antagonist (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone influences siderophore biosynthesis in Pseudomonas putida and Pseudomonas aeruginosa,Appl. Microbiol. Biotechnol., 2005, vol. 66, pp. 689–695.

    Article  CAS  PubMed  Google Scholar 

  91. Zahin, M., Hasan, S., Aqil, F., Khan, M.S., Husain, F.M., and Ahmad, I., Screening of certain medicinal plants from India for their anti-quorum sensing activity, Indian J. Exp. Biol., 2010, vol. 48, pp. 1219–1224.

    PubMed  Google Scholar 

  92. Zhu, H., Liu, W., Tian, B., Liu, H., and Ning, S., Inhibition of quorum sensing in the opportunistic pathogenic bacterium Chromobacterium violaceum by an extract from fruiting bodies of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (higher basidiomycetes), Int. J. Med. Mushrooms, 2011, vol. 13, pp. 559–564.

    Article  PubMed  Google Scholar 

  93. Schulz, S., Dickschat, J.S., Kunze, B., Wagner-Dobler, I., Diestel, R., and Sasse, F., Biological activity of volatiles from marine and terrestrial bacteria, Mar. Drugs, 2010, vol. 8, pp. 2976–2987.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Balick, M.J. and Cox, P.A., Plants, People, and Culture: The Science of Ethnobotany, New York: Scientific American Library, 1999.

    Google Scholar 

  95. Lacassie, E., Marquet, P., Martin-Dupont, S., Gaulier, J.M., and Lachatre, G., A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-electrospray-mass spectrometry, J. Forensic Sci., 2000, vol. 45, pp. 1154–1158.

    Article  CAS  PubMed  Google Scholar 

  96. Bussey, H.I., Hawkins, D.W., Gaspard, J.J., and Walsh, R.A., A comparative trial of digoxin and digitoxin in the treatment of congestive heart failure, Pharmacotherapy, 1988, vol. 8, pp. 235–240.

    Article  CAS  PubMed  Google Scholar 

  97. Downie, J.A., The roles of extracellular proteins, polysaccharides and signals in the interactions of rhizobia with legume roots, FEMS Microbiol. Rev., 2010, vol. 34, pp. 150–170.

    Article  CAS  PubMed  Google Scholar 

  98. Khafagi, I.K. and Dewedar, A., The efficiency of random versus ethno-directed research in the evaluation of Sinai medicinal plants for bioactive compounds, J. Ethnopharmacol., 2000, vol. 71, pp. 365–376.

    Article  CAS  PubMed  Google Scholar 

  99. Dewick, P.M., Medicinal Natural Products: A Biosynthetic Approach, New York: Wiley, 2002, 2nd ed.

    Google Scholar 

  100. Cowan, M.M., Plant products as antimicrobial agents, Clin. Microbiol. Rev., 1999, vol. 12, pp. 564–582.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Tsao, C.Y., Wang, L., Hashimoto, Y., Yi, H., March, J.C., DeLisa, M.P., Wood, T.K., Valdes, J.J., and Bentley, W.E., LuxS coexpression enhances yields of recombinant proteins in Escherichia coli in part through posttranscriptional control of GroEL, Appl. Environ. Microbiol., 2011, vol. 77, pp. 2141–2152.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Kim, K., Kim, Y.U., Koh, B.H., Hwang, S.S., Kim, S.H., Lepine, F., Cho, Y.H., and Lee, G.R., HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kappaB pathway, Immunology, 2010, vol. 129, pp. 578–588.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Wang, Y., Deng, C., Peng, Q., Chen, Z., Huang, D., Zhang, J., and Song, F., Effect of quorum sensing response regulator nprR deletion on expression of cry protein in Bacillus thuringiensis,Wei Sheng Wu Xue Bao, 2010, vol. 50, pp. 1550–1555.

    CAS  PubMed  Google Scholar 

  104. Diţu, L.M., Chifiriuc, C., Lazar, V., and Mihaescu, G., Implication of quorum sensing phenomenon in the expression of genes that code for bacteriocines in lactic bacteria, Bacteriol. Virusol. Parazitol. Epidemiol., 2009, vol. 54, pp. 147–166.

    PubMed  Google Scholar 

  105. Lazar, V., Miyazaki, Y., Hanawa, T., Chifiriuc, M.C., Diţu, L.M., Maruţescu, L., Bleotu, C., and Kamiya, S., The influence of some probiotic supernatants on the growth and virulence features expression of several selected enteroaggregative E. coli clinical strains, Roum. Arch. Microbiol. Immunol., 2009, vol. 68, pp. 207–214.

    PubMed  Google Scholar 

  106. Blumenthal, M., Goldberg, A., and Brinckmann, J., Herbal Medicine: Expanded Commission E Monographs, Newton, MA: Integrat. Med. Comm., 2000.

    Google Scholar 

  107. Chun, S.S., Vattem, D.A., Lin, Y.T., and Shetty, K., Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori,Proc. Biochem., 2005, vol. 40, pp. 809–816.

    Article  CAS  Google Scholar 

  108. Rodrigues, M.R., Krause, L.C., Caramo, E.B., dos Santos, J.G., Dariva, C., and Vladimir de Oliveira, J., Chemical composition and extraction yield of the extract of Origanum vulgare obtained from sub- and supercritical CO2, J. Agric. Food Chem., 2004, vol. 52, pp. 3042–3047.

    Article  CAS  PubMed  Google Scholar 

  109. Chami, F., Chami, N., Bennis, S., Trouillas, J., and Remmal, A., Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model, J. Antimicrob. Chemother., 2004, vol. 54, pp. 909–914.

    Article  CAS  PubMed  Google Scholar 

  110. Hersch-Martinez, P., Leanos-Miranda, B.E., and Solórzano-Santos, F., Antibacterial effects of commercial essential oils over locally prevalent pathogenic strains in Mexico, Fitoterapia, 2005, vol. 76, pp. 453–457.

    Article  CAS  PubMed  Google Scholar 

  111. Saeed, A.M. and Sabir, A.W., Antibacterial activities of some constituents from oleo-gum-resin of Commiphora mukul,Fitoterapia, 2004, vol. 75, pp. 204–208.

    Article  PubMed  CAS  Google Scholar 

  112. Mendez, C. and Salas, J.A., The role of ABC transporters in antibiotic-producing organisms: Drug secretion and resistance mechanisms, Res. Microbiol., 2001, vol. 152, pp. 341–350.

    Article  CAS  PubMed  Google Scholar 

  113. Hogan, D.A., Vik, A., and Kolter, R., A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology, Mol. Microbiol., 2004, vol. 54, pp. 1212–1223.

    Article  CAS  PubMed  Google Scholar 

  114. Persson, T., Hansen, T.H., Rasmussen, T.B., Skindersoe, M.E., Givskov, M., and Neilsen, J., Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic, Org. Biomol. Chem., 2005, vol. 3, pp. 253–262.

    Article  CAS  PubMed  Google Scholar 

  115. Rasmussen, T.B., Bjarnsholt, T., Skindersoe, M.E., Hentzer, M., Kristoffersen, P., Kote, M., Nielsen, J., Eberl, L., and Givskov, M., Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI Selector, J. Bacteriol., 2005, vol. 187, pp. 1799–1814.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Teplitski, M., Robinson, J.B., and Bauer, W.D., Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density–dependent behaviors in associated bacteria, Mol. Plant–Microbe Interact., 2000, vol. 13, pp. 637–648.

    Article  CAS  PubMed  Google Scholar 

  117. Vattem, D.A., Mihalik, K., Crixell, S.H., and McLean, R.J.C., Dietary phytochemicals as quorum sensing inhibitors, Fitoterapia, 2007, vol. 78, pp. 302–310.

    Article  CAS  PubMed  Google Scholar 

  118. Nascimento, G.G.F., Locatelli, J., Freitas, P.C., and Silva, G.L., Antimicrobial activity of plant extracts and phytochemicals on antibiotic resistant bacteria, Braz. J. Microbiol., 2000, vol. 31, pp. 247–256.

    Google Scholar 

  119. Walker, T.S., Bais, H.P., Deziel, E., Schweizer, H.P., Rahme, L.G., Fall, R., and Vivanco, J.M., Pseudomonas aeruginosa–plant root interactions. Pathogenicity, biofilm formation, and root exudation, Plant Physiol., 2004, vol. 134, pp. 320–331.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  120. Huber, B., Eberl, L., Feucht, W., and Polster, J., Influence of polyphenols on bacterial biofilm formation and quorum-sensing, Z. Naturforsch. C: Biosci., 2004, vol. 58, pp. 879–884.

    Article  Google Scholar 

  121. Al-Hussaini, R. and Mahasneh, A.M., Microbial growth and quorum sensing antagonist activities of herbal plants extracts, Molecules, 2009, vol. 14, pp. 3425–3435.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Krishnan, T., Yin, W.F., and Chan, K.G., Inhibition of quorum sensing controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium Aromaticum) bud extract, Sensors, 2012, vol. 12, pp. 4016–4030.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Boga, C., Forlani, L., Calienni, R., Hindley, T., Hochkoeppler, A., Tozzi, S., and Zanna, N., On the antibacterial activity of roots of Capparis spinosa L., Nat. Prod. Res., 2011, vol. 25, pp. 417–421.

    Article  CAS  PubMed  Google Scholar 

  124. Issac Abraham, S.V., Palani, A., Ramaswamy, B.R., Shunmugiah, K.P., and Arumugam, V.R., Antiquorum sensing and antibiofilm potential of Capparis spinosa,Arch. Med. Res., 2011, vol. 42, pp. 658–668.

    Article  PubMed  Google Scholar 

  125. Chong, Y.M., Yin, W.F., Ho, C.Y., Mustafa, M.R.,  Hadi, A.H.A., Awang, K., Narrima, P., and Koh, C.L.,  Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity, J. Nat. Prod., 2011, vol. 74, pp. 2261–2264.

    Article  CAS  PubMed  Google Scholar 

  126. Singh, B.N., Singh, H.B., Singh, A., Singh, B.R., Mishra, A., and Nautiyal, C.S., Lagerstroemia speciosa fruit extract modulates quorum sensing-controlled virulence factor production and biofilm formation in Pseudomonas aeruginosa,Microbiology, 2012, vol. 158, pp. 529–538.

    Article  CAS  PubMed  Google Scholar 

  127. Tan, L.Y., Yin, W.F., and Chan, K.G., Silencing quorum sensing through extracts of Melicope lunu-ankenda,Sensors, 2012, vol. 12, pp. 4339–4351.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Yeo, S.S.M. and Tham, F.Y., Anti-quorum sensing and antimicrobial activities of some traditional Chinese medicinal plants commonly used in South-East Asia, Malaysian J. Microbiol., 2012, vol. 8, pp. 11–20.

    Google Scholar 

  129. Ronald, P.C., Small protein-mediated quorum sensing in a Gram-negative bacterium: Novel targets for control of infectious disease, Discov. Med., 2011, vol. 12, pp. 461–470.

    PubMed  Google Scholar 

  130. Bouyahya, A., Dakka, N., Et-Touys, A., Abrini, J., and Bakri, Y., Medicinal plant products targeting quorum sensing for combating bacterial infections, Asian Pac. J. Trop. Med., 2017, vol. 10, no. 8, pp. 729–743.

    Article  CAS  PubMed  Google Scholar 

  131. Kalia, V.C., Quorum sensing inhibitors: An overview, Biotechnol. Adv., 2013, vol. 31, pp. 224–245.

    Article  CAS  PubMed  Google Scholar 

  132. Amara, N., Krom, B.P., Kaufmann, G.F., and Meijler, M.M., Macromolecular inhibition of quorum sensing: Enzymes, antibodies, and beyond, Chem. Rev., 2011, vol. 111, pp. 195–208.

    Article  CAS  PubMed  Google Scholar 

  133. Kalia, V.C. and Purohit, H.J., Quenching the quorum sensing system: Potential antibacterial drug targets, Crit. Rev. Microbiol., 2011, vol. 37, pp. 121–140.

    Article  CAS  PubMed  Google Scholar 

  134. Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, J. Clin Invest., 2003, vol. 112, pp. 1460–1465.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  135. Rasmussen, T.B. and Givskov, M., Quorum sensing inhibitors: A bargain of effects, Microbiology, 2006, vol. 152, pp. 895–904.

    Article  CAS  PubMed  Google Scholar 

  136. Miyairi, S., Tateda, K., Fuse, E.T., Ueda, C., Saito, H., et al., Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection, J. Med. Microbiol., 2006, vol. 55, pp. 1381–1387.

    Article  CAS  PubMed  Google Scholar 

  137. Hirakawa, H., Harwood, C.S., Pechter, K.B., Schaefer, A.L., and Greenberg, E.P., Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression, Proc. Natl. Acad. Sci. U. S. A., 2012, vol. 109, pp. 12 141–12 146.

    Article  Google Scholar 

  138. Umesha, S. and Shivakumar, J., Bacterial quorum sensing and it is applications in biotechnology, Int. J. Pharm. Biol. Sci., 2013, vol. 4, pp. 850–861.

    CAS  Google Scholar 

  139. Winson, M.K., Swift, S., Fish, L., Throup, J.P., Jørgensen, F., et al., Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing, FEMS Microbiol. Lett., 1998, vol. 163, pp. 185–192.

    Article  CAS  PubMed  Google Scholar 

  140. Steindler, L. and Venturi, V., Detection of quorum-sensing N-acyl homoserine lactone signal molecules by bacterial biosensors, FEMS Microbiol. Lett., 2007, vol. 266, pp. 1–9.

    Article  CAS  PubMed  Google Scholar 

  141. Yu, Y.A., Shabahang, S., Timiryasova, T.M., Zhang, Q., Beltz, R., et al., Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins, Nat. Biotechnol., 2004, vol. 22, pp. 313–320.

    Article  CAS  PubMed  Google Scholar 

  142. Anderson, J.C., Clarke, E.J., Arkin, A.P., and Voigt, C.A., Environmentally controlled invasion of cancer cells by engineered bacteria, J. Mol Biol., 2006, vol. 355, pp. 619–627.

    Article  CAS  PubMed  Google Scholar 

  143. Dong, Y., Wang, L.H., and Zhang, L.H., Quorum-quenching microbial infections: Mechanisms and implications, Philos. Trans. R. Soc. Lond. B: Biol. Sci., 2007, vol. 362, pp. 1201–1211.

    Article  CAS  Google Scholar 

  144. Moghaddam, M.M., Khodi, S., and Mirhosseini, A., Quorum sensing in bacteria and a glance on Pseudomonas aeruginosa,Clin. Microbiol., 2014, vol. 3, p. 156. https://doi.org/10.4172/2327-5073.1000156

    Article  CAS  Google Scholar 

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  1. Department of Pharmaceutical chemistry, Himalayan Institute of Pharmacy Research, 248007, Dehradun, (Uttarakhand), India

    M. Asif

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, PO Box 840, Rafha 91911, Saudi Arabia

    M. Imran

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Asif, M., Imran, M. Effect of Quorum Sensing Inhibitor Agents against Pseudomonas aeruginosa. Russ J Bioorg Chem 46, 149–164 (2020). https://doi.org/10.1134/S1068162020020041

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