Abstract

Reaction of solid-phase catalytic heterogeneous isotope exchange of 2-deoxy-D-glucose and its derivative, O(6)-(4-bromothiophenyl)guanine-C8-β-D-glucose with tritium has been studied. It was shown that performing the reaction of solid-phase catalytic heterogeneous isotope exchange under comparatively mild conditions at 110–120°C enables synthesis of rather labile tritium-labeled compounds, such as 2-deoxy-D-glucose and O(6)-(4-bromothiophenyl)guanine-C8-β-D-glucose. The molar radioactivities of the compounds obtained were 6.1 and 7.9 Ci/mmol, respectively.

中文翻译：

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Tri标记的脱氧葡萄糖及其衍生物的合成

摘要

研究了2-脱氧-D-葡萄糖及其衍生物O（6）-（4-溴硫代苯基）鸟嘌呤-C8-β- D-葡萄糖与solid的固相催化异质同位素交换。结果表明，在相对温和的条件下于110–120°C进行固相催化异质同位素交换反应，可以合成相当不稳定的tri标记的化合物，例如2-deoxy- D - glucose和O（6）- （4-溴硫代苯基）鸟嘌呤-C8-β- D-葡萄糖。得到的化合物的摩尔放射性分别为6.1和7.9 Ci / mmol。