Skip to main content
SpringerLink
Log in

Synthesis of Tritium-Labeled Deoxyglucose and Its Derivative

  • Published:
Radiochemistry Aims and scope

Abstract

Reaction of solid-phase catalytic heterogeneous isotope exchange of 2-deoxy-D-glucose and its derivative, O(6)-(4-bromothiophenyl)guanine-C8-β-D-glucose with tritium has been studied. It was shown that performing the reaction of solid-phase catalytic heterogeneous isotope exchange under comparatively mild conditions at 110–120°C enables synthesis of rather labile tritium-labeled compounds, such as 2-deoxy-D-glucose and O(6)-(4-bromothiophenyl)guanine-C8-β-D-glucose. The molar radioactivities of the compounds obtained were 6.1 and 7.9 Ci/mmol, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme
Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. Baitov, A.A., Sidorov, G.V., and Myasoedov, N.F., Radiochemistry, 2010, vol. 52, no. 5, p. 556. https://doi.org/10.1134/S106636221005019X

    Article  CAS  Google Scholar 

  2. Akulov, G.P., Snetkova, E.V., Kayumov, V.G., and Kaminskii, Yu.L., Radiokhimiya, 1987, vol. 29, no. 5, p. 666.

    CAS  Google Scholar 

  3. Isbell, H.S., Frush, H.L., and Moyer, J.D., J. Res. Natl. Bur. Stand. A: Phys. Chem., 1960, vol. 64A, no. 4, p. 359.

    Article  Google Scholar 

  4. Deschams, J., Rousseau, B., and Beaucourt, J.P., J. Label. Compd. Radiopharm., 1988, vol. 25, no. 11, p. 1281. https://doi.org/10.1002/jlcr.2580251115

    Article  Google Scholar 

  5. Sidorov, G.V. and Myasoedov, N.F., Radiochemistry, 2006, vol. 48, no. 5, p. 517. https://doi.org/10.1134/S1066362206050225

    Article  CAS  Google Scholar 

  6. Sidorov, G.V. and Myasoedov, N.F., Radiochemistry, 2015, vol. 57, no. 1, p. 108. https://doi.org/10.1134/S1066362215010178

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, 123182, Moscow, Russia

    G. V. Sidorov & N. F. Myasoedov

Authors
  1. G. V. Sidorov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. F. Myasoedov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. V. Sidorov.

Ethics declarations

CONFLICT OF INTERESTS

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sidorov, G.V., Myasoedov, N.F. Synthesis of Tritium-Labeled Deoxyglucose and Its Derivative. Radiochemistry 62, 260–263 (2020). https://doi.org/10.1134/S1066362220020150

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1066362220020150

Keywords:

Search

Navigation