Abstract

Effect of carbon substrates materials (graphene oxide, reduced graphene oxide, single-walled carbon nanotubes) on the result of tritium introduction into dalargin peptide was studied by the thermal activation method. It was shown that, when dalargin is deposited onto carbon substrates, the distribution of tritium over amino-acid residues strongly changes as compared with a thick target deposited directly onto glass walls of a vessel. It was demonstrated that, when dalargin is deposited onto the carbon materials studied, the content of tritium in phenylalanine substantially increases, which indicates that the isotope exchange reaction occurs by the electrophilic mechanism. It was also found that the content of tritium in other amino-acid residues substantially changes, which is due to the difference between the structures of adsorption layers of the peptide, formed n the carbon materials under consideration.

中文翻译：

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氧化石墨烯和碳纳米管对Da原子与达拉根反应的影响

摘要

通过热活化方法研究了碳基质材料（氧化石墨烯，还原氧化石墨烯，单壁碳纳米管）对da引入达拉金肽中的影响。结果表明，当达拉根沉积在碳基质上时，与直接沉积在容器玻璃壁上的厚靶相比，over在氨基酸残基上的分布发生了很大变化。已经证明，当将达拉根沉积在所研究的碳材料上时，苯丙氨酸中t的含量显着增加，这表明同位素交换反应是通过亲电机理发生的。还发现其他氨基酸残基中of的含量发生了实质性变化，