Abstract
Effect of carbon substrates materials (graphene oxide, reduced graphene oxide, single-walled carbon nanotubes) on the result of tritium introduction into dalargin peptide was studied by the thermal activation method. It was shown that, when dalargin is deposited onto carbon substrates, the distribution of tritium over amino-acid residues strongly changes as compared with a thick target deposited directly onto glass walls of a vessel. It was demonstrated that, when dalargin is deposited onto the carbon materials studied, the content of tritium in phenylalanine substantially increases, which indicates that the isotope exchange reaction occurs by the electrophilic mechanism. It was also found that the content of tritium in other amino-acid residues substantially changes, which is due to the difference between the structures of adsorption layers of the peptide, formed n the carbon materials under consideration.
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REFERENCES
Lee, A.J., et al., Amino Acids, 2015, vol. 47, no. 5, p. 91.
Saljoughian, M. and Williams, P., Curr. Pharm. Des., 2000, vol. 6, no. 10, p. 1029.
Myasoedov, N.F., J. Label. Compd. Radiopharm., 1993, vol. 33, no. 5, p. 391. https://doi.org/10.1002/jlcr.2580330505
Lockley, W.J.S., J. Label. Compd. Radiopharm., 2007, vol. 50, nos. 5–6, p. 256. https://doi.org/10.1002/jlcr.1232
Shevchenko, V.P., Nagaev, I.Y., and Myasoedov, N.F., J. Label. Compd. Radiopharm., 2010, vol. 53, nos. 11–12, p. 693. https://doi.org/10.1002/jlcr.1828
Kopylov, A.T., et al., Rapid Commun. Mass Spectrom., 2016, vol. 30, no. 11, p. 128.
Hickey, M.J., et al., J. Label. Compd. Radiopharm., 2007, vol. 50, nos. 5–6, p. 286. https://doi.org/10.1002/jlcr.1233
Shevchenko, V.P., Nagaev, I.Yu., and Myasoedov, N.F., Radiochemistry, 2012, vol. 54, no. 1, p. 79. https://doi.org/10.1134/S1066362212010122
Kozlowska, M., Kanski, R., and Kanska, M., J. Label. Compd. Radiopharm., 2005, vol. 48, no. 3, p. 23. https://doi.org/10.1002/jlcr.919
Zhang, Y., J. Label. Compd. Radiopharm., 2017, vol. 60, no. 13, p. 608. https://doi.org/10.1002/jlcr.3559
Egan, J.A. and Filer, C.N., J. Radioanal. Nucl. Chem., 2016, vol. 307, no. 1, p. 549. https://doi.org/10.1007/s10967-015-4158-6
Pajak M., et al., J. Radioanal. Nucl. Chem., 2018, vol. 317, no. 2, p. 643. https://doi.org/10.1007/s10967-018-5932-z
Neiman, L.A., Smolyakov, V.S., and Shishkov, A.V., Itogi Nauki Tekh., Moscow: Moskva, 1985.
Girard, H.A.T., et al., Chem. Commun., 2014, vol. 50, no. 22, p. 2916.
Bush, G.A., et al., J. Biol. Chem., 1981, vol. 256, no. 23, p. 12213.
Filatov, E.S. and Simonov, E.F., Fiziko-khimicheskie i yaderno-khimicheskie sposoby polucheniya mechenykh soedinenii i ikh identifikatsiya (Physicochemical and Nuclear-Chemical Methods for Obtaining Labeled Compounds and Identification of These), Moscow: Energoatomizdat, 1987.
Badun, G.A., Chernysheva, M.G., and Ksenofontov, A.L., Radiochim. Acta, 2012, vol. 100, no. 6, p. 401.
Badun, G.A., et al., Radiochim. Acta, 2016, vol. 104, no. 8, p. 593.
Badun, G.A., et al., Radiochim. Acta, 2014, vol. 102, no. 10, p. 941.
Tsetlin, V.I.T., et al., Eur. J. Biochem., 1988, vol. 178, no. 1, p. 123.
Agafonov, D.E., Kolb, V.A., and Spirin, A.S., Proc. Natl. Acad. Sci., US National Academy of Sciences, 1997, vol. 94, no. 24, p. 12892.
Bogacheva, E.N., et al., Proc. Natl. Acad. Sci., 1998, vol. 95, no. 6, p. 2790.
Razzhivina, I.A., et al., Radiochemistry, 2019, vol. 61, no. 1, p. 66. https://doi.org/10.1134/S1066362219010107
Plotnikov, E.Y., et al., Toxicol. Lett., 2013, vol. 220, no. 3, p. 303.
Schroeder, U., Sommerfeld, P., and Sabel, B.A., Peptides, 1998, vol. 19, no. 4, p. 777.
Tadzhibova, L.T., et al., Bull. Exp. Biol. Med., 2011, vol. 150, no. 3, p. 304.
Tran, D.N.H., Kabiri, S., and Losic, D., Carbon, 2014, vol. 76, p. 193. https://doi.org/10.1016/j.carbon.2014.04.067
Chernysheva, M.G., et al., Colloids Surf., A, 2017, vol. 520, p. 1
Stepanov, K.V., et al., Vest. Mosk. Univ., Ser. 2, Khim., 2005, vol. 46, no. 6, p. 395.
Razzhivina, I.A., Candidate Sci (Chem.) Dissertation, Moscow, 2019.
Zolotarev, Y.A., et al., Amino Acids, 2003, vol. 24, no. 3, p. 325.
Shevchenko, V.P., Nagaev, I.Yu., and Myasoedov, N.F., Radiochemistry, 2018, vol. 60, no. 2, p. 105. https://doi.org/10.1134/S1066362218020017
Filatov, E.S., Simonov, E.F., and Orlova, M.A., Russ. Chem. Rev., 1981, vol. 50, no. 12, p. 1134. https://doi.org/10.1070/RC1981v050n12ABEH002750
Prins, R., Chem. Rev., 2012, vol. 112, no. 5, p. 2714.
Lipson, A.G., et al., Int. J. Hydrogen Energy, 2012, vol. 37, no. 7, p. 5676.
Pham, V.H., et al., J. Mater. Chem., A, 2013, vol. 1, no. 4, p. 1070.
Silambarasan, D., et al., ACS Appl. Mater. Interfaces, 2013, vol. 5, no. 21, p. 11419.
Pazun, J.L., J. Chem. Inf. Model., 1993, vol. 33, no. 6, p. 931.
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The study was supported by the Russian Foundation for Basic Research (grant no. 18-33-20147-mol-a -ved).
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Chernysheva, M.G., Bunyaev, V.A. & Badun, G.A. Effect of Graphene Oxide and Carbon Nanotubes on the Reaction of Tritium Atoms with Dalargin. Radiochemistry 62, 264–269 (2020). https://doi.org/10.1134/S1066362220020162
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DOI: https://doi.org/10.1134/S1066362220020162