Abstract

Stimforte in a wide range of concentrations (15–225 µg/mL) totally inhibits the cytopathic activity of hepatitis C virus (HCV) in the Vero-V cell culture. Interferons (IFN) play the most important role in the suppression of infection when the drug is introduced into the culture before the infection. When Stimforte is introduced after the infection, the mechanism of action seems to be different. The activators of IFN production are mainly (or exclusively) the ligands of receptor complexes TLR-4 and NOD-2 contained in the drug. The action of these substances is probably synergistic, similar to the action of LPS and MDP in Vero-V cells.

中文翻译：

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Stimforte效应对激活靶细胞防御病毒感染的作用的机制。

摘要

多种浓度的Stimforte（15–225 µg / mL）完全抑制了Vero-V细胞培养物中丙型肝炎病毒（HCV）的细胞病变活性。当在感染前将药物引入培养物中时，干扰素（IFN）在抑制感染中起着最重要的作用。在感染后引入Stimforte时，作用机理似乎有所不同。IFN产生的激活剂主要是（或排他地）包含在药物中的受体复合物TLR-4和NOD-2的配体。这些物质的作用可能具有协同作用，类似于Vero-V细胞中LPS和MDP的作用。