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The Mechanism of the Stimforte Effect on the Activation of Target Cell Defense against Viral Infection

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Abstract

Stimforte in a wide range of concentrations (15–225 µg/mL) totally inhibits the cytopathic activity of hepatitis C virus (HCV) in the Vero-V cell culture. Interferons (IFN) play the most important role in the suppression of infection when the drug is introduced into the culture before the infection. When Stimforte is introduced after the infection, the mechanism of action seems to be different. The activators of IFN production are mainly (or exclusively) the ligands of receptor complexes TLR-4 and NOD-2 contained in the drug. The action of these substances is probably synergistic, similar to the action of LPS and MDP in Vero-V cells.

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Authors and Affiliations

  1. ZAO SKY LTD, 129301, Moscow, Russia

    D. G. Mal’dov & A. V. Ilichev

  2. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia

    P. G. Deryabin, S. S. Grigoryan, D. V. Mishin, V. L. Andronova, E. I. Isaeva & G. A. Galegov

Authors
  1. D. G. Mal’dov
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  2. P. G. Deryabin
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  3. S. S. Grigoryan
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  4. D. V. Mishin
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  5. V. L. Andronova
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  6. E. I. Isaeva
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  7. G. A. Galegov
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  8. A. V. Ilichev
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Corresponding author

Correspondence to D. G. Mal’dov.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by E. Makeeva

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Mal’dov, D.G., Deryabin, P.G., Grigoryan, S.S. et al. The Mechanism of the Stimforte Effect on the Activation of Target Cell Defense against Viral Infection. Dokl Biol Sci 491, 50–53 (2020). https://doi.org/10.1134/S0012496620020076

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  • DOI: https://doi.org/10.1134/S0012496620020076

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