Abstract

Blockade of α6, α3β2, α9α10, and α7 subtypes of nicotinic acetylcholine receptors slows tumor growth in vivo, increases cytotoxic activity of splenocytes from tumor-bearing mice, and, to some extent, reduces the viability of Ehrlich carcinoma cells in vitro. These data indicate that nicotinic acetylcholine receptors are involved in oncogenesis, affecting the survival of tumor cells, inter alia, via modulation of the antitumor immunity.

中文翻译：

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烟碱型乙酰胆碱受体的阻滞剂延迟肿瘤生长并增加小鼠脾细胞的抗肿瘤活性。

摘要

尼古丁乙酰胆碱受体的α6，α3β2，α9α10和α7亚型的阻滞减慢了体内肿瘤的生长，增加了荷瘤小鼠脾细胞的细胞毒性活性，并在一定程度上降低了艾氏癌细胞的体外生存能力。这些数据表明，烟碱乙酰胆碱受体参与肿瘤发生，特别是通过调节抗肿瘤免疫力，影响肿瘤细胞的存活。