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Blockers of Nicotinic Acetylcholine Receptors Delay Tumor Growth and Increase Antitumor Activity of Mouse Splenocytes

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Blockade of α6, α3β2, α9α10, and α7 subtypes of nicotinic acetylcholine receptors slows tumor growth in vivo, increases cytotoxic activity of splenocytes from tumor-bearing mice, and, to some extent, reduces the viability of Ehrlich carcinoma cells in vitro. These data indicate that nicotinic acetylcholine receptors are involved in oncogenesis, affecting the survival of tumor cells, inter alia, via modulation of the antitumor immunity.

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REFERENCES

  1. Chen, J., Cheuk, I.W.Y., Shin, V.Y., et al., Surg. Oncol., 2019, vol. 31, pp. 46–53.

    Article  Google Scholar 

  2. Friedman, J.R., Richbart, S.D., Merritt, J.C., et al., Pharmacol. Ther., 2019, vol. 194, pp. 222–254.

    Article  CAS  Google Scholar 

  3. Pavlov, V.A., Chavan, S.S., and Tracey, K.J., Annu. Rev. Immunol., 2018, vol. 36, pp. 783–812.

    Article  CAS  Google Scholar 

  4. Terpinskaya, T.I., Osipov, A.V., Kuznetsova, T.E., et al., Dokl. Biochem. Biophys., 2015, vol. 463, pp. 216–219.

    Article  CAS  Google Scholar 

  5. Dutertre, S., Nicke, A., and Tsetlin, V.I., Neuropharmacology, 2017, vol. 127, pp. 196–223.

    Article  CAS  Google Scholar 

  6. Zhmak, M.N., Kasheverov, I.E., Utkin, Yu.N., et al., Russ. J. Bioorg. Chem., 2001, vol. 27, no. 2, pp. 83–88.

    Article  CAS  Google Scholar 

  7. Osipov, A.V., Terpinskaya, T.I., Ulaschik, V.S., et al., Dokl. Biochem. Biophys., 2013, vol. 451, pp. 207–208.

    Article  CAS  Google Scholar 

  8. Zhang, X., Rao, A., Sette, P., et al., Neuro Oncol., 2016, vol. 18, no. 10, pp. 1402–1412.

    Article  CAS  Google Scholar 

  9. Kawashima, K., Fujii, T., Moriwaki, Y., et al., Int. Immunopharmacol., 2015, vol. 29, no. 1, pp. 127–134.

    Article  CAS  Google Scholar 

  10. Hensel, J.A., Khattar, V., Ashton, R., et al., Lab. Invest., 2019, vol. 99, no. 1, pp. 93–106.

    Article  CAS  Google Scholar 

  11. Shao, S., Risch, E., Burner, D., et al., Int. Immunopharmacol., 2017, vol. 47, pp. 159–165.

    Article  CAS  Google Scholar 

  12. Castro, F., Cardoso, A.P., Gonçalves, R.M., et al., Front. Immunol., 2018, vol. 9, p. 847.

    Article  Google Scholar 

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ACKNOWLEDGMENTS

We are grateful to Dr. M.N. Zhmak for the synthesis of conotoxins.

Funding

This work was supported by the Russian Foundation for Basic Research (project no. 18-54-00031) and the Belarusian National Foundation for Basic Research (project M18R-104).

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Authors and Affiliations

  1. Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

    T. I. Terpinskaya, T. V. Balashevich, T. L. Yanchanka & E. A. Tamashionik

  2. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    A. V. Osipov,  V. I. Tsetlin & Yu. N. Utkin

Authors
  1. T. I. Terpinskaya
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  2. A. V. Osipov
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  3. T. V. Balashevich
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  4. T. L. Yanchanka
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  5. E. A. Tamashionik
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  6. V. I. Tsetlin
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  7. Yu. N. Utkin
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Corresponding author

Correspondence to A. V. Osipov.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. Studies using animal models were approved by the Bioethics Committee of the Institute of Physiology, National Academy of Sciences of Belarus, Minutes no. 1 of January 31, 2019.

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Translated by M. Batrukova

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Terpinskaya, T.I., Osipov, A.V., Balashevich, T.V. et al. Blockers of Nicotinic Acetylcholine Receptors Delay Tumor Growth and Increase Antitumor Activity of Mouse Splenocytes. Dokl Biochem Biophys 491, 89–92 (2020). https://doi.org/10.1134/S1607672920020143

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  • DOI: https://doi.org/10.1134/S1607672920020143

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