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Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-06-01 , DOI: 10.1134/s1607672920020155
S D Varfolomeev 1 , V I Bykov 2 , S B Tsybenova 2
Affiliation  

Abstract

A kinetic model describing the dynamics of synaptic “discharge” taking into account the kinetics of the injection of the neurotransmitter into the synaptic cleft, the pH-dependence of the catalytic activity of the enzyme, and diffusion withdrawal of protons is proposed. The model provides a physicochemical explanation for a number of important physiological phenomena, such as the neuromuscular paralysis, the molecular mechanism of neurological memory, and the effect of some neurotoxins and drugs.


中文翻译:

人脑中化学过程的动力学。胆碱能突触功能机制中的乙酰胆碱酯酶和pH脉冲的质子阻断。

摘要

提出了一种动力学模型,该模型描述了突触“放电”的动力学,该模型考虑了将神经递质注射到突触间隙中的动力学,酶催化活性的pH依赖性以及质子的扩散撤离。该模型为许多重要的生理现象提供了物理化学解释,例如神经肌肉麻痹,神经记忆的分子机制以及某些神经毒素和药物的作用。
更新日期:2020-06-01
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