Abstract

A kinetic model describing the dynamics of synaptic “discharge” taking into account the kinetics of the injection of the neurotransmitter into the synaptic cleft, the pH-dependence of the catalytic activity of the enzyme, and diffusion withdrawal of protons is proposed. The model provides a physicochemical explanation for a number of important physiological phenomena, such as the neuromuscular paralysis, the molecular mechanism of neurological memory, and the effect of some neurotoxins and drugs.

中文翻译：

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人脑中化学过程的动力学。胆碱能突触功能机制中的乙酰胆碱酯酶和pH脉冲的质子阻断。

摘要

提出了一种动力学模型，该模型描述了突触“放电”的动力学，该模型考虑了将神经递质注射到突触间隙中的动力学，酶催化活性的pH依赖性以及质子的扩散撤离。该模型为许多重要的生理现象提供了物理化学解释，例如神经肌肉麻痹，神经记忆的分子机制以及某些神经毒素和药物的作用。