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Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

A kinetic model describing the dynamics of synaptic “discharge” taking into account the kinetics of the injection of the neurotransmitter into the synaptic cleft, the pH-dependence of the catalytic activity of the enzyme, and diffusion withdrawal of protons is proposed. The model provides a physicochemical explanation for a number of important physiological phenomena, such as the neuromuscular paralysis, the molecular mechanism of neurological memory, and the effect of some neurotoxins and drugs.

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Funding

This work was supported by the Russian Science Foundation (project no. 18-13-00030).

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Authors and Affiliations

  1. Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intellegence, Moscow State University, 119991, Moscow, Russia

    S. D. Varfolomeev

  2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    V. I. Bykov & S. B. Tsybenova

Authors
  1. S. D. Varfolomeev
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  2. V. I. Bykov
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  3. S. B. Tsybenova
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Correspondence to V. I. Bykov.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Varfolomeev, S.D., Bykov, V.I. & Tsybenova, S.B. Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse. Dokl Biochem Biophys 491, 85–88 (2020). https://doi.org/10.1134/S1607672920020155

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  • DOI: https://doi.org/10.1134/S1607672920020155

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