Abstract Six new lanthanide(III) complexes, namely [Gd III (QL1) 3 (BL1)] ( Gd1 ), [Gd III (QL1) 3 (BL2)] ( Gd2 ), [Lu III (QL2) 2 (BL3)(NO 3 )] ( Lu1 ), [Lu III (QL2) 2 (BL2)(NO 3 )] ( Lu2 ), [Yb III (QL3) 2 (BL2)(NO 3 )] ( Yb1 ), and [Yb III (QL4) 2 (BL2)(NO 3 )] ( Yb2 ) coordinated with 5,7-dibromo-8-quinolinol (H-QL1), 5,5′-dimethyl-2,2′-bipyridyl (BL1), 4,4′-di-tert-butyl-2,2′-bipyridine (BL2), 5,7-dibromo-2-methylquinolin-8-ol (H-QL2), 2,2′-bipyridine (BL3), 5,7-dichloro-8-hydroxyquinoline (H-QL3), and 5,7-dichloro-8-hydroxy-2-methylquinoline (H-QL4), were prepared. The Ln III complexes Gd1 , Gd2 , Lu1 , Lu2 , Yb1 and Yb2 showed high cytotoxicity toward cervical (HeLa), ovarian (SK-OV-3) and lung (NCI-H460) cancer cells with IC 50 values from 0.18 ± 0.14 to 8.02 ± 1.71 μM. In addition, Yb1 and Yb2 impaired mitochondrial functions, decreased mitochondrial membrane potential, and altered the levels of mitochondrial related-proteins. The apoptosis-inducing capability was in the order of Yb2 > Yb1 . Such observed differences in biological activities could be caused by the electronic effect of the methyl group of H-QL4 in Yb2 . Graphic abstract

中文翻译：

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六种镧系元素 (III) 与 5,7-二卤代-8-喹啉醇和 2,2'-联吡啶衍生物配合物的合成、表征和抗癌活性

摘要 六种新型镧系元素(III)配合物，即[Gd III (QL1) 3 (BL1)] ( Gd1 )、[Gd III (QL1) 3 (BL2)] ( Gd2 )、[Lu III (QL2) 2 (BL3) (NO 3 )] ( Lu1 ), [Lu III (QL2) 2 (BL2)(NO 3 )] ( Lu2 ), [Yb III (QL3) 2 (BL2)(NO 3 )] ( Yb1 ), 和 [Yb III (QL4) 2 (BL2)(NO 3 )] ( Yb2 ) 与 5,7-二溴-8-羟基喹啉 (H-QL1)、5,5'-二甲基-2,2'-联吡啶 (BL1) 配位， 4,4'-二叔丁基-2,2'-联吡啶 (BL2), 5,7-二溴-2-甲基喹啉-8-醇 (H-QL2), 2,2'-联吡啶 (BL3),制备了 5,7-二氯-8-羟基喹啉 (H-QL3) 和 5,7-二氯-8-羟基-2-甲基喹啉 (H-QL4)。Ln III 复合物 Gd1、Gd2、Lu1、Lu2、Yb1 和 Yb2 对宫颈癌 (HeLa)、卵巢癌 (SK-OV-3) 和肺癌 (NCI-H460) 癌细胞显示出高细胞毒性，IC 50 值为 0.18 ± 0.14 至8.02±1.71μM。此外，Yb1 和 Yb2 损害线粒体功能，降低线粒体膜电位，并改变线粒体相关蛋白的水平。凋亡诱导能力为Yb2>Yb1。这种观察到的生物活性差异可能是由 Yb2 中 H-QL4 甲基的电子效应引起的。图形摘要