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Synthesis, characterization and the anticancer activity of six lanthanides(III) complexes with 5,7-dihalogenated-8-quinolinol and 2,2’-bipyridine derivatives

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Abstract

Six new lanthanide(III) complexes, namely [GdIII(QL1)3(BL1)] (Gd1), [GdIII(QL1)3(BL2)] (Gd2), [LuIII(QL2)2(BL3)(NO3)] (Lu1), [LuIII(QL2)2(BL2)(NO3)] (Lu2), [YbIII(QL3)2(BL2)(NO3)] (Yb1), and [YbIII(QL4)2(BL2)(NO3)] (Yb2) coordinated with 5,7-dibromo-8-quinolinol (H-QL1), 5,5′-dimethyl-2,2′-bipyridyl (BL1), 4,4′-di-tert-butyl-2,2′-bipyridine (BL2), 5,7-dibromo-2-methylquinolin-8-ol (H-QL2), 2,2′-bipyridine (BL3), 5,7-dichloro-8-hydroxyquinoline (H-QL3), and 5,7-dichloro-8-hydroxy-2-methylquinoline (H-QL4), were prepared. The LnIII complexes Gd1, Gd2, Lu1, Lu2, Yb1 and Yb2 showed high cytotoxicity toward cervical (HeLa), ovarian (SK-OV-3) and lung (NCI-H460) cancer cells with IC50 values from 0.18 ± 0.14 to 8.02 ± 1.71 μM. In addition, Yb1 and Yb2 impaired mitochondrial functions, decreased mitochondrial membrane potential, and altered the levels of mitochondrial related-proteins. The apoptosis-inducing capability was in the order of Yb2 > Yb1. Such observed differences in biological activities could be caused by the electronic effect of the methyl group of H-QL4 in Yb2.

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Acknowledgements

We thank the National Natural Science Foundation of China (Nos. 51963021, 21867017 and 21761033), the Natural Science Foundation of Guangxi (No. 2018GXNSFBA138021, 2018GXNSFBA281188 and 2017GXNSFBA19833), the PhD Research Startup Program of Yulin Normal University (No. G2019ZK14), the China University Students Innovative Project (201910606139), the Innovative Team & Outstanding Talent Program of Colleges and Universities in Guangxi (2017-38), the Basic Skills Improvement Project for the Young and Middle-aged Teachers in Guangxi Colleges and Universities (No. 2019KY1163) and the Innovative Team and Outstanding Talent Program of Colleges and Universities in Guangxi (2014-49 and 2017-38) for financial support.

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  1. Rong Wang and Bi-Qun Zou contributed equally to this work.

Authors and Affiliations

  1. Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, School of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, People’s Republic of China

    Rong Wang, Qi-Pin Qin, Zhen-Feng Wang & Ming-Xiong Tan

  2. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, People’s Republic of China

    Bi-Qun Zou, Qi-Pin Qin & Hong Liang

  3. Department of Chemistry, Guilin Normal College, 9 Feihu Road, Gulin, 541001, People’s Republic of China

    Bi-Qun Zou

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11243_2020_399_MOESM1_ESM.doc

The characterization data of Gd1, Gd2, Lu1, Lu2, Yb1 and Yb2 in this work. In addition, the CCDC numbers for Gd1, Gd2, Lu1, Lu2, Yb1 and Yb2 were 1968346, 1968347, 1968352, 1968353, 1968349 and 1968350. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: (+44) 1223-336-033; or e-mail: deposit@ccdc.cam.ac.uk. (DOC 837 kb)

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Wang, R., Zou, BQ., Qin, QP. et al. Synthesis, characterization and the anticancer activity of six lanthanides(III) complexes with 5,7-dihalogenated-8-quinolinol and 2,2’-bipyridine derivatives. Transit Met Chem 45, 477–483 (2020). https://doi.org/10.1007/s11243-020-00399-4

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