The discovery of novel and critical genes implicated in malignant development is a topic of high interest in cancer research. Intriguingly, a group of genes named “double-agent” genes were reported to have both oncogenic and tumor-suppressive functions. To date, less than 100 “double-agent” genes have been documented. Fubp1 is a master transcriptional regulator of a subset of genes by interacting with a far upstream element (FUSE). Mounting evidence has collectively demonstrated both the oncogenic and tumor suppressive roles of Fubp1 and the debate regarding its roles in tumorigenesis has been around for several years. Therefore, the detailed molecular mechanisms of Fubp1 need to be determined in each context. In the present study, we showed that the Fubp1 protein level was enriched in the S phase and we identified that Fubp1 deficiency altered cell cycle progression, especially in the S phase, by downregulating the mRNA expression levels of Ccna genes encoding cyclin A. Although this Fubp1-cyclin A axis appears to exist in several types of tumors, Fubp1 showed heterogeneous expression patterns among various cancer tissues, suggesting it exhibits multiple and complicated functions in cancer development. In addition, we showed that Fubp1 deficiency confers survival advantages to cells against metabolic stress and anti-cancer drugs, suggesting that Fubp1 may play both positive and negative roles in malignant development.

中文翻译：

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Fubp1在细胞周期进程和细胞存活中的多种功能。

涉及恶性发展的新的关键基因的发现是癌症研究中高度关注的一个话题。有趣的是，据报道有一组名为“双重作用”基因的基因同时具有致癌和抑癌功能。迄今为止，已经记录了不到100个“双试剂”基因。Fubp1是与远上游元件（FUSE）相互作用的一个基因子集的主要转录调节因子。越来越多的证据共同证明了Fubp1的致癌作用和抑癌作用，关于其在肿瘤发生中作用的争论已有数年之久。因此，Fubp1的详细分子机制需要在每种情况下确定。在目前的研究中，Ccna基因编码细胞周期蛋白A。尽管此Fubp1-cyclin A轴似乎存在于多种类型的肿瘤中，但Fubp1在各种癌组织之间显示出异质表达模式，表明它在癌症发展中表现出多种复杂功能。此外，我们表明Fubp1缺乏赋予细胞抵抗代谢应激和抗癌药物的生存优势，这表明Fupp1可能在恶性发展中发挥正负作用。