Background

The TFAP2 family of transcription factors, regulating gene expression related to vertebrate evolution, have been studied extensively in human cancer. However, the distinct roles of each TFAP2 in the expression and prognostic significance of lung carcinoma have not been elucidated yet.

Objective

This study is aimed to identify the mRNA expression and prognostic value of TFAP2 family in human lung cancer.

Methods

The transcriptional and survival data of TFAP2s in patients with lung cancer were obtained via ONCOMINE, LinkedOmics, GEPIA, cBioPortal, Kaplan–Meier Plotter and Human Protein Atlas databases.

Results

The results showed that expression levels of TFAP2A and TFAP2C were higher in lung adenocarcinoma and squamous cell carcinoma tissues than in normal lung tissues, whereas no difference was found in the TFAP2B expression level. TFAP2A was related to an unfavorable overall survival in lung cancer and its upregulation was significantly related to the overall survival in patients with smoking, non-chemotherapy and non-radiotherapy.

Conclusion

This study implied that TFAP2A was a reliable prognostic factor, which could be a potential marker for improving survival and prognostic accuracy of lung cancer patients.

中文翻译：

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TFAP2在人肺癌中的表达和预后的综合分析。

背景

TFAP2家族的转录因子调节与脊椎动物进化有关的基因表达，已在人类癌症中进行了广泛研究。然而，尚未阐明每种TFAP2在肺癌的表达和预后意义中的独特作用。

目的

这项研究旨在确定TFAP2家族在人类肺癌中的mRNA表达和预后价值。

方法

TFAP2s在肺癌患者中的转录和存活数据通过ONCOMINE，LinkedOmics，GEPIA，cBioPortal，Kaplan-Meier绘图仪和人蛋白图谱数据库获得。

结果

结果显示，在肺腺癌和鳞状细胞癌组织中，TFAP2A和TFAP2C的表达水平高于正常肺组织，而在TFAP2B的表达水平中没有发现差异。TFAP2A与肺癌的总体生存不良有关，其上调与吸烟，非化学疗法和非放射疗法患者的总体生存显着相关。

结论

这项研究表明，TFAP2A是可靠的预后因素，可能是改善肺癌患者生存率和预后准确性的潜在标志。