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Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma

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Abstract

Background

The TFAP2 family of transcription factors, regulating gene expression related to vertebrate evolution, have been studied extensively in human cancer. However, the distinct roles of each TFAP2 in the expression and prognostic significance of lung carcinoma have not been elucidated yet.

Objective

This study is aimed to identify the mRNA expression and prognostic value of TFAP2 family in human lung cancer.

Methods

The transcriptional and survival data of TFAP2s in patients with lung cancer were obtained via ONCOMINE, LinkedOmics, GEPIA, cBioPortal, Kaplan–Meier Plotter and Human Protein Atlas databases.

Results

The results showed that expression levels of TFAP2A and TFAP2C were higher in lung adenocarcinoma and squamous cell carcinoma tissues than in normal lung tissues, whereas no difference was found in the TFAP2B expression level. TFAP2A was related to an unfavorable overall survival in lung cancer and its upregulation was significantly related to the overall survival in patients with smoking, non-chemotherapy and non-radiotherapy.

Conclusion

This study implied that TFAP2A was a reliable prognostic factor, which could be a potential marker for improving survival and prognostic accuracy of lung cancer patients.

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Acknowledgements

This study was supported by grants from post-doctor research project, West China Hospital, Sichuan University (Grant no. 18HXBH013). The authors appreciated Pro. Xue Zhao form Sichuan University, for her kind help in grammar revision and suggestion regarding this manuscript. All the listed authors made substantial contributions as follows: study concept and design and obtained funding: Cai-Qi Cheng, Lin-Yong Zhao; draft manuscript: Cai-Qi Cheng, Lin-Yong Zhao; analysis and interpretation of data: Cai-Qi Cheng, Zhisen Ai.

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Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, Department of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu, China

    Caiqi Cheng

  2. West China School of Medicine, Sichuan University, Chengdu, China

    Zhisen Ai & Linyong Zhao

  3. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan Province, China

    Linyong Zhao

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  1. Caiqi Cheng
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  2. Zhisen Ai
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Correspondence to Linyong Zhao.

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The authors, Caiqi Cheng, Zhisen Ai and Linyong Zhao declare that they have no conflict of interest.

Ethical approval

The study was approved by the Ethics Committee of West China College of Stomatology, Sichuan University. Informed consent was waived because all data involving the individual participants included in the study were from the public database and their private information was concealed prior to evaluation.

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Cheng, C., Ai, Z. & Zhao, L. Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma. Genes Genom 42, 779–789 (2020). https://doi.org/10.1007/s13258-020-00948-2

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