Recent efforts have revealed that long non-coding RNAs exert crucial roles in cancer initiation and progression. RHPN1-AS1 is a 2030 bp transcript from human chromosome 8q24, and involved in tumorigenesis in uveal melanoma and non-small cell lung cancer, but it remains unknown in ovarian cancer. This study focused on the role of RHPN1-AS1 in ovarian cancer and found that RHPN1-AS1 was up-regulated in ovarian cancer tissues and cell lines. Overexpression of RHPN1-AS1 promoted ovarian cancer cell proliferation, migration, and invasion. Mechanistically, overexpression of RHPN1-AS1 decreased the expression of miR-665 and subsequently promoted the expression of Akt3 at posttranscriptional level. Taken together, RHPN1-AS1 positively regulated the expression of Akt3 through sponging miR-665, and exerted an oncogenic role in ovarian cancer progression, and indicates that RHPN1-AS1 may be a potential therapeutic target in ovarian cancer.

最近的研究表明，长链非编码 RNA 在癌症的发生和发展中发挥着至关重要的作用。RHPN1-AS1 是来自人类染色体 8q24 的 2030 bp 转录物，参与葡萄膜黑色素瘤和非小细胞肺癌的肿瘤发生，但它在卵巢癌中仍然未知。本研究关注 RHPN1-AS1 在卵巢癌中的作用，发现 RHPN1-AS1 在卵巢癌组织和细胞系中上调。RHPN1-AS1的过表达促进卵巢癌细胞增殖、迁移和侵袭。从机制上讲，RHPN1-AS1 的过表达降低了 miR-665 的表达，随后在转录后水平上促进了 Akt3 的表达。总之，RHPN1-AS1通过海绵miR-665正向调节Akt3的表达，并在卵巢癌进展中发挥致癌作用，