The review highlights the main results of two decades of research on climacostol (5-[(2Z)-non-2-en-1-yl]benzene-1,3-diol), the resorcinolic lipid produced and used by the ciliated protozoan Climacostomum virens for chemical defense against a wide range of predators, and to assist its carnivorous feeding. After the first studies on the physiological function of climacostol, the compound and some analogues were chemically synthesized, thus allowing us to explore both its effect on different prokaryotic and eukaryotic biological systems, and the role of its relevant structural traits. In particular, the results obtained in the last 10 years indicate climacostol is an effective antimicrobial and anticancer agent, bringing new clues to the attempt to design and synthesize additional novel analogues that can increase or optimize its pharmacological properties.

中文翻译：

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纤毛虫次生代谢产物Climacostol的自然功能和结构修饰。

这篇综述着重介绍了二十年来对纤毛虫产生和使用的间苯二酚脂质类的西马甾醇（5-[（2 Z）-非-2-en-1-基]苯-1,3-二醇）的研究成果。原生动物Climacostomum virens 化学防御各种捕食者，并协助其肉食性摄食。在对金刚烷醇的生理功能进行了首次研究之后，该化合物及其一些类似物已化学合成，从而使我们能够探索其对不同原核生物和真核生物系统的作用及其相关结构性状的作用。特别是，最近10年获得的结果表明，西马可甾醇是一种有效的抗微生物剂和抗癌剂，为尝试设计和合成可增加或优化其药理特性的其他新型类似物提供了新的线索。