Current pharmacological approaches have failed to provide complete remission for patients with Attention-Deficit/Hyperactivity Disorder (ADHD). This study aimed to evaluate the efficacy and tolerability of resveratrol (that have been shown to have antioxidative, anti-inflammatory, and anti-apoptotic effects) as an adjunct to methylphenidate in pharmacologic treatment of ADHD. This 8-week, double-blinded, placebo-controlled trial randomized 66 participants to receive either 500 mg/day resveratrol or matched placebo in addition to methylphenidate. ADHD symptoms were evaluated in the patients using the Parent and Teacher versions of ADHD-Rating Scale (ADHD-RS) at three measurement points with time intervals of 4 weeks. Furthermore, the tolerability of the treatment strategies was systematically compared. Repeated measures analysis demonstrated a significant effect for time-treatment interaction on all three subscales of the Parent ADHD-RS during the trial period (total: p = 0.015; inattention: p = 0.032; hyperactivity/impulsivity: p = 0.036). Nevertheless, the effect for time-treatment interaction was not significant for the Teacher version of ADHD-RS (total: F = 0.81, df = 1.33, p = 0.401; inattention: F = 0.57, df = 1.37, p = 0.507; hyperactivity/impulsivity: F = 0.65, df = 1.34, p = 0.466). The frequencies of complications in the treatment groups were similar. Resveratrol administration for a duration of 8 weeks improved characteristic symptoms in patients with ADHD according to their parents. Further investigations containing larger sample sizes, longer supplementation periods, and dose-response evaluations are required to replicate these findings in ADHD children more confidently.

中文翻译：

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白藜芦醇与哌醋甲酯辅助治疗可改善注意力不足/多动症的症状：一项随机，双盲，安慰剂对照的临床试验。

当前的药理学方法未能为注意力缺乏/多动症（ADHD）患者提供完全缓解。这项研究旨在评估白藜芦醇（已显示具有抗氧化，抗炎和抗凋亡作用）作为哌醋甲酯在ADHD药物治疗中的辅助剂的功效和耐受性。这项为期8周，双盲，安慰剂对照的试验将66名参与者随机分配为接受500毫克/天的白藜芦醇或匹配的安慰剂，以及哌醋甲酯。使用父母和教师版的ADHD评分量表（ADHD-RS）在患者的三个测量点以4周的时间间隔评估ADHD症状。此外，系统地比较了治疗策略的耐受性。重复测量分析表明，在试验期间，时间-治疗相互作用对父母ADHD-RS的所有三个分量表都有显着影响（总计：p = 0.015；注意力不集中：p = 0.032；活动过度/冲动：p = 0.036）。但是，对于教师版的ADHD-RS，时间-治疗相互作用的影响并不显着（总计：F = 0.81，df = 1.33，p = 0.401;注意力不集中：F = 0.57，df = 1.37，p = 0.507;过度活跃/冲动性：F ＝ 0.65，df ＝ 1.34，p ＝ 0.466）。治疗组的并发症发生频率相似。据其父母称，白藜芦醇给药持续8周可改善ADHD患者的典型症状。进一步的调查包括更大的样本量，更长的补充期限，