Introduction and hypothesis The association between overactive bladder (OAB) and uterine prolapse remains unclear. The extent of the role of serum nerve growth factor (NGF) levels in this relationship is also not known. Therefore, our study evaluated the association among OAB, high-grade uterine prolapse and serum NGF levels. Methods A total of 90 patients participated in our study and were grouped as follows. Group I included patients with high-grade uterine prolapse and OAB, group II included patients with only high-grade uterine prolapse, and group III included healthy women without uterine prolapse or OAB. Serum NGF level analysis was performed in all groups. Results Serum NGF levels varied greatly among the three groups, with significantly higher levels in group 1 than in groups 2 and 3 ( p < 0.001). Serum NGF levels with a cutoff point of 120.49 pg/ml identified women with significant OAB symptoms to discriminate among groups with a sensitivity of 80%, specificity of 86.7%, positive predictive value of 75.0%, negative predictive value of 89.7% and positive likelihood ratio of 6.01 ( p < 0.001). Conclusions Our study showed that NGF-related pathways may play an active role in the pathophysiology of OAB with high-grade uterine prolapse patients based on obstruction hypothesis.

中文翻译：

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高度子宫脱垂女性膀胱过度活动症与血清神经生长因子浓度的关系

引言和假设 膀胱过度活动症 (OAB) 与子宫脱垂之间的关联仍不清楚。血清神经生长因子 (NGF) 水平在这种关系中的作用程度也是未知的。因此，我们的研究评估了 OAB、高度子宫脱垂和血清 NGF 水平之间的关联。方法 共有 90 名患者参加了我们的研究，分组如下。第 I 组包括患有高级别子宫脱垂和 OAB 的患者，第 II 组包括仅患有高级别子宫脱垂的患者，第 III 组包括没有子宫脱垂或 OAB 的健康女性。在所有组中进行血清NGF水平分析。结果三组血清NGF水平差异较大，1组显着高于2、3组（p<0.001）。截止点为 120.49 pg/ml 的血清 NGF 水平可识别出具有显着 OAB 症状的女性，以区分敏感性为 80%、特异性为 86.7%、阳性预测值为 75.0%、阴性预测值为 89.7% 和阳性可能性的组比率为 6.01 (p < 0.001)。结论 我们的研究表明，基于梗阻假说，NGF 相关通路可能在高级别子宫脱垂患者 OAB 的病理生理学中发挥积极作用。