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Association between overactive bladder and serum nerve growth factor concentrations in women with high-grade uterine prolapse

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Abstract

Introduction and hypothesis

The association between overactive bladder (OAB) and uterine prolapse remains unclear. The extent of the role of serum nerve growth factor (NGF) levels in this relationship is also not known. Therefore, our study evaluated the association among OAB, high-grade uterine prolapse and serum NGF levels.

Methods

A total of 90 patients participated in our study and were grouped as follows. Group I included patients with high-grade uterine prolapse and OAB, group II included patients with only high-grade uterine prolapse, and group III included healthy women without uterine prolapse or OAB. Serum NGF level analysis was performed in all groups.

Results

Serum NGF levels varied greatly among the three groups, with significantly higher levels in group 1 than in groups 2 and 3 (p < 0.001). Serum NGF levels with a cutoff point of 120.49 pg/ml identified women with significant OAB symptoms to discriminate among groups with a sensitivity of 80%, specificity of 86.7%, positive predictive value of 75.0%, negative predictive value of 89.7% and positive likelihood ratio of 6.01 (p < 0.001).

Conclusions

Our study showed that NGF-related pathways may play an active role in the pathophysiology of OAB with high-grade uterine prolapse patients based on obstruction hypothesis.

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References

  1. Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: report from the standardization sub-committee of the international continence society. Neurourol Urodyn. 2012;12:167–78.

    Google Scholar 

  2. Geppetti P, Nassini R, Materazzi S, et al. The concept of neurogenic inflammation. BJU Int. 2008;101:2–6.

    Article  CAS  Google Scholar 

  3. Slieker-ten Hove MC, Pool-Goudzwaard AL, Eijkemans MJ, Steeegers-Theunissen RP, Burger CW, Vierhout ME. The prevalence of pelvic organ prolapse symptoms and signs and ther relation with bladder and bowel disorders in general female population. Int Urogynecol J Pelvic Floor Dysfınct. 2009;20(9):1037–45.

    Article  Google Scholar 

  4. De Boer T, Salvatore S, Cardozo L, et al. Pelvic organ prolapse and overactive bladder. Neurourol Urodyn. 2010;29(1):30–9.

    Article  Google Scholar 

  5. Baker SA, Hatton WJ, Han J, et al. Role of TREK-1 potassium channel in bladder overactivity after partial bladder outlet obstruction in mouse. J Urol. 2010;183:793–800.

    Article  CAS  Google Scholar 

  6. Steers WD, Tuttle JB. Mechanism of disease: the role of nerve growth factor in the pathophysiology of bladder disorders. Nat Clin Pract Urol. 2006;3(2):101–10.

    Article  CAS  Google Scholar 

  7. Cruz F. Mechanism involved in new therapies for overactive bladder. Urology. 2004;63:65–73.

    Article  Google Scholar 

  8. Kim JC, Kim DB, Seo SI, et al. Nerve growth factor and vanilloid receptor expression, and detrusor instability, after relieving bladder outlet obstruction in rats. BJU Int. 2004;94:915–8.

    Article  CAS  Google Scholar 

  9. Baker SA, Hennig GW, Han J, et al. Methionine and its derivatives increase bladder overactivity by inhibiting stretch dependent K (+) channels. Br J Pharmacol. 2008;153:1259–71.

    Article  CAS  Google Scholar 

  10. Anger JT, Goldman HB, Luo X, et al. Patterns of medical management of overactive bladder (OAB) and benign prostatic hyperplasia (BPH) in the United States. Neurourol Urodyn. 2018;37(1):213–22.

    Article  Google Scholar 

  11. Tarcan T, Mangır N, Ozgur MO, Akbal C. OAB-V8 overactive bladder questionnaire validation study. Üroloji Bülteni. 2012;21:113–6.

    Google Scholar 

  12. Bump RC, Mattiasson A, Bo K, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 1996;175:10–7.

    Article  CAS  Google Scholar 

  13. Cam C, Sakalli M, Ay P, Cam M, Karateke A. Validation of the short forms of the incontinence impact questionnaire (IIQ-7) and the urogenital distress inventory (UDI-6) in a Turkish population. Neurounal Urodyn. 2007;26:129–33.

    Article  Google Scholar 

  14. Dagdeviren H, Cengiz H. Association between metabolic syndrome and serum nerve growth factor levels in women with overactive bladder. Gynecol Obstet Investig. 2018;83(2):140–4.

    Article  CAS  Google Scholar 

  15. Steers WD, Kolbeck S, Creedon D, Tuttle JB. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest. 1991;88:1709–15.

    Article  CAS  Google Scholar 

  16. Liu HT, Lin H, Kuo HC. Increased serum nerve growth factor levels in patients with overactive bladder syndrome refractory to antimuscarinic therapy. Neurorol Urodyn. 2011;30:1525–9.

    Article  Google Scholar 

  17. Bonini S, Lambiase A, Bonini S, et al. Nerve growth factor: an important molecule in allergic inflammation and tissue remodeling. Int Arch Allergy Immunol. 1999;118:159–92.

    Article  CAS  Google Scholar 

  18. Bonini S, Lambiase A, Bonini S, et al. Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc Natl Acad Sci U S A. 1996;93:10955–60.

    Article  CAS  Google Scholar 

  19. Serrano-Sanchez T, Robinson-Agramonte MA, Lorigados-Pedro L. Endogenous nerve growth factor in patients with Alzheimer’s disease. Rev Neurol. 2001;32:825–8.

    CAS  PubMed  Google Scholar 

  20. Stanzani L, Zoia C, Sala G, et al. Nerve growth factor and transforming growth factor-beta serum levels in acute stroke patients. Possible involvement of neurotrophins in cerebrovascular disease. Cerebrovasc Dis. 2001;12:240–4.

    Article  CAS  Google Scholar 

  21. Jäger W, Mirenska O, Brügge S. Surgical treatment of mixed and urge urinary incontinence in women. Gynecol Obstet Investig. 2012;74:157–64.

    Article  Google Scholar 

  22. Miranne JM, Lopes V, Carberry CL, Sung VW. The effect of pelvic organ prolapse severity on improvement in overactive bladder symptoms after pelvic reconstructive surgery. Int Urogynecol J. 2013;24:1303–8.

    Article  Google Scholar 

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Acknowledgements

We thank the American Journal Experts team for language editing assistance.

Funding

All the authors report no funding or financial support for this study.

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Authors and Affiliations

  1. University of Health Sciences Istanbul, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology, 34180, Istanbul, Turkey

    Şükrü Yildiz, Cihan Kaya, İsmail Alay & Murat Ekin

  2. Istanbul Aydin University, Faculty of Medicine, Department of Obstetrics and Gynecology, 34140, Istanbul, Turkey

    Hüseyin Cengiz

  3. University of Health Sciences Istanbul, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Deparment of Biochemistry, 34180, Istanbul, Turkey

    Alev Kural

Authors
  1. Şükrü Yildiz
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  2. Hüseyin Cengiz
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  3. Alev Kural
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  4. Cihan Kaya
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  5. İsmail Alay
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  6. Murat Ekin
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Contributions

S Yildiz: Project development, Study design and Manuscript writing.

H Cengiz: Data collection, Data analysis.

A Kural: Data collection.

C Kaya: Data collection, Data analysis.

I Alay: Data collection, Data analysis.

M Ekin: Supervision.

Corresponding author

Correspondence to Şükrü Yildiz.

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Yildiz, Ş., Cengiz, H., Kural, A. et al. Association between overactive bladder and serum nerve growth factor concentrations in women with high-grade uterine prolapse. Int Urogynecol J 32, 345–351 (2021). https://doi.org/10.1007/s00192-020-04336-y

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  • DOI: https://doi.org/10.1007/s00192-020-04336-y

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