BACKGROUND Ovarian cancer is the deadliest of gynecologic malignancies with the 5-year overall survival rate remaining at approximately 30%, a rate that has not improved over the last three decades. Standard of care for epithelial ovarian cancer patients consists of a platinum compound with a taxane given intravenously following debulking surgery; however, 80% of cases relapse within 2 years of diagnosis. This review sought to identify key underlying biomarkers related to platinum resistance in ovarian cancer to establish possible prognostic biomarkers of chemoresponse. METHODS A systematic literature review was conducted across three databases PubMed, EMBASE and SCOPUS to summarise the evidence for prognostic biomarkers in platinum-resistant ovarian cancer patients. RESULTS Forty-eight human studies were used in the review encompassing 6719 participants in retrospective and prospective study designs. A total of 68 biomarkers were reported that were significantly correlated with chemoresponse and/or survival reporting a p value less than or equal to 0.05. CONCLUSION This review accentuates the pleiotropic phenotypic complexities related to the response to platinum therapy in ovarian cancer. A one-size-fits-all approach may be ineffective in a large portion of patients, emphasising the need for a whole system-based approach and personalised treatment strategies. Identifying key biomarkers to aid clinical decision-making is the first essential step in developing and appropriating therapies for at-risk patients, reducing toxicity and improving quality of life.

中文翻译：

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一项系统的文献综述，评估遗传生物标记物是否是卵巢癌患者基于铂的化疗反应的预测因子。

背景技术卵巢癌是最致命的妇科恶性肿瘤，其5年总生存率保持在30％左右，该比率在过去的30年中没有改善。上皮性卵巢癌患者的护理标准是由铂化合物和紫杉烷组成，这些化合物是在大型手术后静脉注射的。但是，有80％的病例在诊断后2年内复发。这项审查试图确定与卵巢癌铂耐药相关的关键基础生物标志物，以建立化学反应的可能预后生物标志物。方法对三个数据库PubMed，EMBASE和SCOPUS进行了系统的文献综述，总结了铂耐药性卵巢癌患者预后生物标志物的证据。结果回顾性和前瞻性研究设计共纳入48项人体研究，包括6719名参与者。总共报告了68个生物标志物，其与化学反应和/或存活报告的ap值小于或等于0.05显着相关。结论这篇评论强调了与卵巢癌铂治疗反应有关的多效性表型复杂性。一种一刀切的方法可能对大部分患者无效，强调了对基于整个系统的方法和个性化治疗策略的需求。识别关键的生物标志物以帮助临床决策是开发和使用高危患者疗法，降低毒性并改善生活质量的第一步。