Adolescent girls and young women (AGYW) ages (15–24 years old) in Southern and Eastern Africa account for nearly 30% of all new HIV infections. We conducted a systematic review of studies examining the effectiveness of behavioral, structural, and combined (behavioral + structural) interventions on HIV incidence and risky sexual behaviors among AGYW. Following PRISMA guidelines, we searched PubMed, CINAHL, Web of Science, and Global Health. Twenty-two studies met inclusion criteria conducted in Eastern and Southern Africa and comprised behavioral, structural, or combined (behavioral and structural) interventions. All findings are based on 22 studies. HIV incidence was significantly reduced by one structural intervention. All three types of interventions improved condom use among AGYW. Evidence suggests that structural interventions can reduce HIV incidence, while behavioral and combined interventions require further investigation.

南部和东部非洲的年龄在15-24岁之间的少女和年轻女性（AGYW）占所有新感染HIV的近30％。我们对研究进行了系统的回顾，以检查行为，结构和联合（行为+结构）干预措施对AGYW中HIV感染率和危险性行为的有效性。按照PRISMA指南，我们搜索了PubMed，CINAHL，Web of Science和Global Health。22项研究符合在东部和南部非洲进行的纳入标准，包括行为，结构或组合（行为和结构）干预措施。所有发现均基于22项研究。通过一项结构性干预，艾滋病毒的发病率大大降低。所有这三种类型的干预措施均能改善AGYW中的安全套使用情况。