The metabolic syndrome is a complex disorder of various metabolic risk factors in a single individual having central obesity and commonly associated with diabetes and cardiovascular diseases. The aim of our study was to study the relationship between coagulation abnormalities and metabolic syndrome. We performed a prospective cross-sectional study in a tertiary care hospital. A total of fifty cases of metabolic syndrome and fifty age & sex matched controls were selected. These two groups were investigated for Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen levels, Plasminogen Activator Inhibitor 1(PAI1) levels and Factor VIII levels. In cases with metabolic syndrome, significantly increased levels of Fibrinogen, Factor VIII and Plasminogen Activator Inhibitor1 (PAI1) were observed. PT & APTT were shorter in cases with metabolic syndrome. The coagulation parameters studied, correlated significantly with the components of metabolic syndrome. Metabolic syndrome is a hypercoagulable state and further studies are required for further evaluation of the consequences of this hypercoagulable state. There is a need for clinical trials evaluating prophylactic anticoagulation for prevention of venous thrombosis in patients with metabolic syndrome.

中文翻译：

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代谢综合征血栓前变化的研究

代谢综合征是一种复杂的疾病，在单个患有中心性肥胖的个体中具有各种代谢危险因素，通常与糖尿病和心血管疾病有关。我们研究的目的是研究凝血异常与代谢综合征之间的关系。我们在一家三级医院进行了一项前瞻性横断面研究。总共选择了五十例代谢综合征和五十个年龄和性别匹配的对照。研究这两组的凝血酶原时间 (PT)、活化部分凝血活酶时间 (APTT)、纤维蛋白原水平、纤溶酶原激活剂抑制剂 1(PAI1) 水平和因子 VIII 水平。在代谢综合征的病例中，观察到纤维蛋白原、因子 VIII 和纤溶酶原激活剂抑制剂 1 (PAI1) 水平显着增加。PT & 代谢综合征患者的 APTT 较短。研究的凝血参数与代谢综合征的成分显着相关。代谢综合征是一种高凝状态，需要进一步研究以进一步评估这种高凝状态的后果。需要进行临床试验来评估预防性抗凝以预防代谢综合征患者的静脉血栓形成。