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Study of Prothrombotic Changes in Metabolic Syndrome

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Abstract

The metabolic syndrome is a complex disorder of various metabolic risk factors in a single individual having central obesity and commonly associated with diabetes and cardiovascular diseases. The aim of our study was to study the relationship between coagulation abnormalities and metabolic syndrome. We performed a prospective cross-sectional study in a tertiary care hospital. A total of fifty cases of metabolic syndrome and fifty age & sex matched controls were selected. These two groups were investigated for Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen levels, Plasminogen Activator Inhibitor 1(PAI1) levels and Factor VIII levels. In cases with metabolic syndrome, significantly increased levels of Fibrinogen, Factor VIII and Plasminogen Activator Inhibitor1 (PAI1) were observed. PT & APTT were shorter in cases with metabolic syndrome. The coagulation parameters studied, correlated significantly with the components of metabolic syndrome. Metabolic syndrome is a hypercoagulable state and further studies are required for further evaluation of the consequences of this hypercoagulable state. There is a need for clinical trials evaluating prophylactic anticoagulation for prevention of venous thrombosis in patients with metabolic syndrome.

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Authors and Affiliations

  1. Haematology Deptt, Vardhman Mahavir Medical College and Safdar Jang Hospital, New Delhi, 110029, India

    Jitender Mohan Khunger

  2. Medicine Department, Vardhman Mahavir Medical College and Safdar Jang Hospital, New Delhi, 110029, India

    Nitin Kumar & V. P. S. Punia

  3. Department of Hematology and Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA

    Monica Khunger Malhotra

Authors
  1. Jitender Mohan Khunger
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  2. Nitin Kumar
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  3. V. P. S. Punia
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  4. Monica Khunger Malhotra
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Correspondence to Jitender Mohan Khunger.

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Informed consent was obtained from all individual participants included in this study.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or National research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Khunger, J.M., Kumar, N., Punia, V.P.S. et al. Study of Prothrombotic Changes in Metabolic Syndrome. Indian J Hematol Blood Transfus 36, 695–699 (2020). https://doi.org/10.1007/s12288-020-01291-y

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  • DOI: https://doi.org/10.1007/s12288-020-01291-y

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